CAJ | 학술논문

目的：探讨单胺氧化酶A（MAOA）基因活性与注意缺陷多动障碍（ADHD）执行功能的关系。方法：采用威斯康星分类测验和Stroop词色干扰测试对37例ADHD汉族儿童与30名正常对照组进行执行功能评估，采集外周全血并应用限制性片段长度多态性的方法检测MAOA基因启动子30 bp可变数目串联重复倍数，根据重复倍数分别将ADHD组和对照组分为高活性组与低活性组。结果：组别因素对WSCT概念化水平、完成分类数、错误应答数、持续错误数、持续应答数的影响差异均有统计学意义（P＜0.05）；2组间对Stroop色词测验中完成卡片A和卡片C的耗时数差异有统计学意义（P＜0.001），干扰效应的耗时数差异有统计学意义（P＜O.05）；基因活性分组因素对WSCT概念化水平、持续错误数、错误应答数的影响差异有统计学意义（P＜O.05），对Stroop色词测验中的完成卡片A和卡片C的耗时数差异有统计学意义（P＜0.05），干扰效应的耗时数差异有统计学意义（P＜O.05）；ADHD组和正常对照组间MAOA等位基因的分布差异均无统计学意义（P＞0.05）。结论：本研究未发现MAOA-uVNTR各等位基因分布与ADHD存在关联，但可能与ADHD儿童部分执行功能有一定相关性。
목적：탐토단알양화매A（MAOA）기인활성여주의결함다동장애（ADHD）집행공능적관계。방법：채용위사강성분류측험화Stroop사색간우측시대37례ADHD한족인동여30명정상대조조진행집행공능평고，채집외주전혈병응용한제성편단장도다태성적방법검측MAOA기인계동자30 bp가변수목천련중복배수，근거중복배수분별장ADHD조화대조조분위고활성조여저활성조。결과：조별인소대WSCT개념화수평、완성분류수、착오응답수、지속착오수、지속응답수적영향차이균유통계학의의（P＜0.05）；2조간대Stroop색사측험중완성잡편A화잡편C적모시수차이유통계학의의（P＜0.001），간우효응적모시수차이유통계학의의（P＜O.05）；기인활성분조인소대WSCT개념화수평、지속착오수、착오응답수적영향차이유통계학의의（P＜O.05），대Stroop색사측험중적완성잡편A화잡편C적모시수차이유통계학의의（P＜0.05），간우효응적모시수차이유통계학의의（P＜O.05）；ADHD조화정상대조조간MAOA등위기인적분포차이균무통계학의의（P＞0.05）。결론：본연구미발현MAOA-uVNTR각등위기인분포여ADHD존재관련，단가능여ADHD인동부분집행공능유일정상관성。
Objective: To explore the relationship between polymorphism of MAOA gene activity and the executive function of attention-deifcit hyperactivity disorder (ADHD).Methods: Choose 37 patients who was diagnosed as ADHD and 30 normal volunteers as controls. The executive function was evaluated using wisconsin card sorting test (WCST) and Stroop test. Taking peripheral blood and restriction fragment length polymorphism (RFLP) techniques were performed to detect MAOA 30 bp tandem repeats multiple of variable number, accord-ing to this repeats multiple, the case and control groups were divided into high and low activity group, respec-tively.Results: Group factor had signiifcant effects on conceptual level, the number of completely classiifcations, the number of wrong answers, the number of continually mistakes, the number of continually answers in WCST; Group factor also had statistical signiifcant differences on the complete time between A and C card in Stroop test (P<0.001), the time of interference effects also had statistically signiifcant (P<0.05); MAOA gene activity fac-tor had signiifcant inlfuence on conceptual level, the number of continually mistakes and the number of wrong answers had statistically signiifcant on the difference of complete time in STROOP A card and C card (P<0.05), the time of interference effects also had statistically signiifcant (P<0.05). There was no statistically signiifcant in allele distribution of MAOA gene between the ADHD cases group and the control group (P>0.05).Conclusion:Our study ifnd no relationship between MAOA-uVNTR allele distribution and ADHD, However, there maybe have relationship between MAOA polymorphism and part of the executive function.