国际外科学杂志
國際外科學雜誌
국제외과학잡지
International Journal of Surgery
2015年
8期
573-576
,共4页
mRNA剪切和多聚腺苷酸化因子类%肿瘤%RNA前体%Poly (A)结合蛋白质类
mRNA剪切和多聚腺苷痠化因子類%腫瘤%RNA前體%Poly (A)結閤蛋白質類
mRNA전절화다취선감산화인자류%종류%RNA전체%Poly (A)결합단백질류
mRNA cleavage and polyadenylation factors%Neoplasms%RNA precursors%Poly(A)-binding proteins
在人类实体肿瘤中,首选治疗方法是手术切除,但多数临床确诊的肿瘤患者已处于中晚期,失去了手术机会.切割与多聚腺苷酸化特异因子是参与mRNA 3'端的切割和多聚腺嘌呤poly (A)尾的添加,在mRNA成熟和细胞信号转导过程中扮演着重要的角色.在某些条件下,切割与多聚腺苷酸化特异因子表达的异常能导致癌基因的激活,进而引起肿瘤的发生.本文就切割与多聚腺苷酸化特异因子与肿瘤相关研究进行综述.
在人類實體腫瘤中,首選治療方法是手術切除,但多數臨床確診的腫瘤患者已處于中晚期,失去瞭手術機會.切割與多聚腺苷痠化特異因子是參與mRNA 3'耑的切割和多聚腺嘌呤poly (A)尾的添加,在mRNA成熟和細胞信號轉導過程中扮縯著重要的角色.在某些條件下,切割與多聚腺苷痠化特異因子錶達的異常能導緻癌基因的激活,進而引起腫瘤的髮生.本文就切割與多聚腺苷痠化特異因子與腫瘤相關研究進行綜述.
재인류실체종류중,수선치료방법시수술절제,단다수림상학진적종류환자이처우중만기,실거료수술궤회.절할여다취선감산화특이인자시삼여mRNA 3'단적절할화다취선표령poly (A)미적첨가,재mRNA성숙화세포신호전도과정중분연착중요적각색.재모사조건하,절할여다취선감산화특이인자표체적이상능도치암기인적격활,진이인기종류적발생.본문취절할여다취선감산화특이인자여종류상관연구진행종술.
For human solid tumors,the preferred treatment is surgery.However most patients with clinical diagnosis of tumor is already in advanced,and lost the chance of operation.Cleavage and polyadenylation specific factor is involved in mRNA 3' end cleavage and polyadenine (A) tail,and plays an important role in mRNA maturation and intracellular singal transduction.Under certain conditions,cleavage and polyademletion specific factor can lead to abnormal activation of cancer genes,and then cause tumors.Progress in the relation between cleavage and polyademletion specific factor and tumor was reviewed in the paper.
