CAJ | 학술논문

小梁网是青光眼在前房的靶组织,小梁网细胞结构和功能障碍时可引起眼压升高.近年来研究表明,线粒体功能失调和氧化应激在小梁网细胞损伤的过程中起重要作用.线粒体是细胞内有氧呼吸的重要场所,当线粒体功能失调时细胞内ATP合成减少且活性氧生成过多.体内过多的活性氧物质堆积导致线粒体DNA损伤,引起线粒体结构和功能的进一步损伤,反过来生成更多的活性氧物质.活性氧的释放和损伤的线粒体可引起细胞色素C的释放,激活半胱天冬酶途径,诱导细胞凋亡.此外线粒体损伤引起的氧化应激反应还可通过损伤体内大分子物质、诱发炎症反应、介导溶酶体功能失调等途径造成小梁网细胞损伤或死亡.
소량망시청광안재전방적파조직,소량망세포결구화공능장애시가인기안압승고.근년래연구표명,선립체공능실조화양화응격재소량망세포손상적과정중기중요작용.선립체시세포내유양호흡적중요장소,당선립체공능실조시세포내ATP합성감소차활성양생성과다.체내과다적활성양물질퇴적도치선립체DNA손상,인기선립체결구화공능적진일보손상,반과래생성경다적활성양물질.활성양적석방화손상적선립체가인기세포색소C적석방,격활반광천동매도경,유도세포조망.차외선립체손상인기적양화응격반응환가통과손상체내대분자물질、유발염증반응、개도용매체공능실조등도경조성소량망세포손상혹사망.
Trabecular meshwork(TM) is the target tissue of glaucoma in the anterior chamber.TM cell dysfunction could lead to elevated intraocular pressure.Recently,lots of researches found that mitochondrial dysfunction and oxidative stress play the key roles in TM injury.Mitochondria is an important place in aerobic respiration of the cell and it' s dysfunction would end up with reduced intracellular ATP synthesis and increased reactive oxygen species (ROS).Excessive accumulation of ROS may contribute to mitochondrial DNA damage and further injury of the mitochondrial,in turn,generate more ROS.The release of ROS injures the mitochondria lead to the release of cytochrome C,which activated caspase pathway and then induction of cell apoptosis.In addition,oxidative stress caused by mitochondrial dysfunction would contribute to cell death of TM by causing macromolecular substances injury,inducing inflammation or mediating lysosome dysfunction.