CAJ | 학술논문

目的：观察鞣酸软膏预防多西他赛致皮肤坏死的效果。方法将100例通过外周静脉置入静脉留置针行多西他赛化疗的肿瘤患者随机分组，观察组50例，用药后外涂鞣酸软膏，3次／d，连续7 d；对照组50例，用药后予多磺酸黏多糖乳膏外涂，方法同鞣酸软膏。结果观察组和对照组预防多西他赛致皮肤坏死的发生率分别为18％、24％（ P＞0.05）。结论鞣酸软膏预防多西他赛致皮肤坏死的疗效同多磺酸黏多糖乳膏，两者同样具备操作简单、方便等优点，但鞣酸软膏的价格优于多磺酸黏多糖乳膏，值得推广应用。
목적：관찰유산연고예방다서타새치피부배사적효과。방법장100례통과외주정맥치입정맥류치침행다서타새화료적종류환자수궤분조，관찰조50례，용약후외도유산연고，3차／d，련속7 d；대조조50례，용약후여다광산점다당유고외도，방법동유산연고。결과관찰조화대조조예방다서타새치피부배사적발생솔분별위18％、24％（ P＞0.05）。결론유산연고예방다서타새치피부배사적료효동다광산점다당유고，량자동양구비조작간단、방편등우점，단유산연고적개격우우다광산점다당유고，치득추엄응용。
Objective To observate the effiracy of tannic acid ointment on the prevention docetaxel-induced skin necrosis.Methods One hundred cancer patients with docetaxel were divided into two group.Tannic acid ointment and mucopolysaccharide polysulfate cream were applied three times a day for 7 days after using docetaxel in the two groups respectively.Results There was no significant difference on the skin necrosis between the two groups (18%vs 24%, P>0.05) .Conclusions The efficacy of tannic acid ointment on the prevention docetaxel-induced skin necro-sis is the same as mucopolysaccharide polysulfate cream.Except their common virtue of convenient and simple operation, the price of tannic acid ointment is lower than mucopolysaccharide polysulfate cream, and worthy to be spread in clinical practice.