中外医学研究
中外醫學研究
중외의학연구
Chinese and Foreign Medical Research
2015年
27期
1-2,3
,共3页
王旭晴%解福平%毕仲江%殷小成
王旭晴%解福平%畢仲江%慇小成
왕욱청%해복평%필중강%은소성
新生儿缺氧缺血性脑病%神经节苷脂%白介素-23%白介素-17
新生兒缺氧缺血性腦病%神經節苷脂%白介素-23%白介素-17
신생인결양결혈성뇌병%신경절감지%백개소-23%백개소-17
Neonatal hypoxic-ischemic encephalopathy%Ganglioside%Interleukin-23%Interleukin-17
目的：观察神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)的疗效及对血清白介素-23(IL-23)、白介素-17(IL-17)水平的影响，为临床应用神经节苷脂治疗HIE提供依据。方法：将84例HIE患儿分为对照组(n=42)和观察组(n=42)，对照组采用常规治疗，观察组在此基础上加用神经节苷脂，比较两组患儿总有效率、反射恢复时间、肌张力恢复时间、意识恢复时间，于治疗前、后提取血清，应用酶联免疫吸附法(ELISA)检测血清IL-23与IL-17水平。结果：观察组患儿总有效率高于对照组(P<0.05)，反射恢复时间、肌张力恢复时间、意识恢复时间短于对照组(P<0.05)；两组患儿治疗后血清IL-23、IL-17水平均较治疗前降低(P<0.05)，而且观察组治疗后血清IL-23、IL-17水平低于同期对照组(P<0.05)。结论：神经节苷脂治疗HIE疗效显著，抑制IL-23/IL-17炎症轴可能是神经节苷脂治疗HIE的重要机制之一。
目的：觀察神經節苷脂治療新生兒缺氧缺血性腦病(HIE)的療效及對血清白介素-23(IL-23)、白介素-17(IL-17)水平的影響，為臨床應用神經節苷脂治療HIE提供依據。方法：將84例HIE患兒分為對照組(n=42)和觀察組(n=42)，對照組採用常規治療，觀察組在此基礎上加用神經節苷脂，比較兩組患兒總有效率、反射恢複時間、肌張力恢複時間、意識恢複時間，于治療前、後提取血清，應用酶聯免疫吸附法(ELISA)檢測血清IL-23與IL-17水平。結果：觀察組患兒總有效率高于對照組(P<0.05)，反射恢複時間、肌張力恢複時間、意識恢複時間短于對照組(P<0.05)；兩組患兒治療後血清IL-23、IL-17水平均較治療前降低(P<0.05)，而且觀察組治療後血清IL-23、IL-17水平低于同期對照組(P<0.05)。結論：神經節苷脂治療HIE療效顯著，抑製IL-23/IL-17炎癥軸可能是神經節苷脂治療HIE的重要機製之一。
목적：관찰신경절감지치료신생인결양결혈성뇌병(HIE)적료효급대혈청백개소-23(IL-23)、백개소-17(IL-17)수평적영향，위림상응용신경절감지치료HIE제공의거。방법：장84례HIE환인분위대조조(n=42)화관찰조(n=42)，대조조채용상규치료，관찰조재차기출상가용신경절감지，비교량조환인총유효솔、반사회복시간、기장력회복시간、의식회복시간，우치료전、후제취혈청，응용매련면역흡부법(ELISA)검측혈청IL-23여IL-17수평。결과：관찰조환인총유효솔고우대조조(P<0.05)，반사회복시간、기장력회복시간、의식회복시간단우대조조(P<0.05)；량조환인치료후혈청IL-23、IL-17수평균교치료전강저(P<0.05)，이차관찰조치료후혈청IL-23、IL-17수평저우동기대조조(P<0.05)。결론：신경절감지치료HIE료효현저，억제IL-23/IL-17염증축가능시신경절감지치료HIE적중요궤제지일。
Objective:To explore the effect of Ganglioside in the treatment of neonatal hypoxic-ischemic encephalopathy(HIE) and the influence of interleukin-23(IL-23) and interleukin-17(IL-17) levels,thereby to provide the basis for application of ganglioside to treat HIE.Method:84 cases with HIE were randomly divided into the control group(n=42) and the observation group(n=42).The control group were treated with conventional therapy.On the basis of this,the observation group were administrated with Ganglioside.Total effective rate,reflection recovery time,muscle tonus recovery time,and consciousness recovery time were compared between the observation group and the control group.Serum was isolated before and after treatment,enzyme linked immunosorbent assay(ELISA) was then used to detect serum IL-23 and IL-17 levels.Result:In comparison with control group,a significant increase in total effective rate and a significant decrease in reflection recovery time,muscle tonus recovery time and consciousness recovery time in observation group.There were statistical significance(P<0.05).Serum IL-23 and IL-17 levels were lower after treatment than before treatment in two group (P<0.05).Moreover,Serum IL-23 and IL-17 levels were also significantly decreased after treatment in observation group when compared with same period in the control group(P<0.05).Conclusion:Treatment of HIE with Ganglioside has good curative effects.Inhibition of the IL-23/IL-17 inflammatory axis may be one of significant mechanisms by which Ganglioside treats HIE.
