CAJ | 학술논문

目的观察睾丸非霍奇金淋巴瘤的临床病理表现及免疫表型,探讨其临床病理学特征.方法对2008年1月1日至2014年11月30日期间收治的65例睾丸非霍奇金淋巴瘤患者进行回顾性临床病理研究.结果全部65例患者中,46例(70.8％)为原发性睾丸淋巴瘤(PTL),19例(29.2％)为继发性睾丸淋巴瘤(STL).PTL和STL患者均表现为睾丸不同程度的肿大,伴或不伴疼痛,且多为单侧受累(分别占91.3％和84.2％).PTL患者中位发病年龄明显大于STL患者,分别为65(12～88)岁和13(1～75)岁,差异有统计学意义(P＜0.001);两组病例的组织学分型亦存在明显的不同,其中PTL中以弥漫大B细胞淋巴瘤(DLBCL)最为常见(87.0％);而STL则以B淋巴母细胞淋巴瘤(B-LBL)最为常见(57.9％).结论睾丸非霍奇金淋巴瘤以PTL多见,STL相对少见.与STL相比,PTL更多见于老年人.DLBCL是PTL最常见的组织学亚型,而STL中则以B-LBL更为常见.
목적 관찰고환비곽기금림파류적림상병리표현급면역표형,탐토기림상병이학특정.방법 대2008년1월1일지2014년11월30일기간수치적65례고환비곽기금림파류환자진행회고성림상병리연구.결과 전부65례환자중,46례(70.8％)위원발성고환림파류(PTL),19례(29.2％)위계발성고환림파류(STL).PTL화STL환자균표현위고환불동정도적종대,반혹불반동통,차다위단측수루(분별점91.3％화84.2％).PTL환자중위발병년령명현대우STL환자,분별위65(12～88)세화13(1～75)세,차이유통계학의의(P＜0.001);량조병례적조직학분형역존재명현적불동,기중PTL중이미만대B세포림파류(DLBCL)최위상견(87.0％);이STL칙이B림파모세포림파류(B-LBL)최위상견(57.9％).결론 고환비곽기금림파류이PTL다견,STL상대소견.여STL상비,PTL경다견우노년인.DLBCL시PTL최상견적조직학아형,이STL중칙이B-LBL경위상견.
Objective To summarize the clinicopathological features of testicular lymphomas (TL).Methods The medical records of 65 patients diagnosed with TL between 2008.1.1 and 2014.11.30 were retrospectively reviewed.Results TL was classified as primary (PTL) when there' s no prior diagnosis of an extara-testicular lymphoma/leukemia and no concurrent widespread disease,except for the concomitant involvement of ipsilateral inguinal lymph nodes;otherwise it was classified as secondary (STL).Of our patients group,46 (70.8％) cases were classified primary TL as and the other 19 (29.2％) cases were secondary TL.All patients presented with painless testicular swelling.The median age of STL was significantly younger than that of PTL [65 (12-88) ys vs 13 (1-75) ys,P＜0.001].Additionally,a striking difference in the distribution of histological subtypes was observed between the PTL and STL patients group.Conclusion Primary TLs were more common than secondary.Striking differences in the distribution of patients' age and histology were found between STL and PTL.