临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
Chinese Journal of Clinical Rational Drug Use
2015年
27期
14-15,18
,共3页
肺结核%氧氟沙星%抗结核药%治疗结果
肺結覈%氧氟沙星%抗結覈藥%治療結果
폐결핵%양불사성%항결핵약%치료결과
Pulmonary tuberculosis%Ofloxacin%Antitubercular agents%Treatment outcome
目的：探讨左氧氟沙星辅助抗结核药物治疗耐多药肺结核的临床疗效。方法选取2010年3月—2013年8月攀枝花市第四人民医院收治的耐多药肺结核患者140例，随机分为研究组与对照组，各70例。研究组患者予以左氧氟沙星辅助抗结核药物治疗，对照组患者予以常规抗结核药物治疗。观察两组患者治疗3、6、12个月及治疗后1个月痰菌转阴情况、影像学疗效（结核灶改善疗效、肺空洞改善疗效）及不良反应（胃肠道反应、肝功能轻度受损、肾功能轻度受损、头晕乏力）发生情况。结果研究组患者治疗3个月及治疗后1个月痰菌转阴率高于对照组，差异有统计学意义（P ﹤0.05）；两组患者治疗6、12个月痰菌转阴率比较，差异无统计学意义（ P ﹥0.05）；研究组患者结核灶改善疗效和肺空洞改善疗效优于对照组，差异有统计学意义（ P ﹤0.05）；两组患者不良反应发生率比较，差异无统计学意义（P ﹥0.05）。结论左氧氟沙星辅助抗结核药物治疗耐多药肺结核的临床疗效显著，可有效杀灭结核杆菌，且不良反应少。
目的：探討左氧氟沙星輔助抗結覈藥物治療耐多藥肺結覈的臨床療效。方法選取2010年3月—2013年8月攀枝花市第四人民醫院收治的耐多藥肺結覈患者140例，隨機分為研究組與對照組，各70例。研究組患者予以左氧氟沙星輔助抗結覈藥物治療，對照組患者予以常規抗結覈藥物治療。觀察兩組患者治療3、6、12箇月及治療後1箇月痰菌轉陰情況、影像學療效（結覈竈改善療效、肺空洞改善療效）及不良反應（胃腸道反應、肝功能輕度受損、腎功能輕度受損、頭暈乏力）髮生情況。結果研究組患者治療3箇月及治療後1箇月痰菌轉陰率高于對照組，差異有統計學意義（P ﹤0.05）；兩組患者治療6、12箇月痰菌轉陰率比較，差異無統計學意義（ P ﹥0.05）；研究組患者結覈竈改善療效和肺空洞改善療效優于對照組，差異有統計學意義（ P ﹤0.05）；兩組患者不良反應髮生率比較，差異無統計學意義（P ﹥0.05）。結論左氧氟沙星輔助抗結覈藥物治療耐多藥肺結覈的臨床療效顯著，可有效殺滅結覈桿菌，且不良反應少。
목적：탐토좌양불사성보조항결핵약물치료내다약폐결핵적림상료효。방법선취2010년3월—2013년8월반지화시제사인민의원수치적내다약폐결핵환자140례，수궤분위연구조여대조조，각70례。연구조환자여이좌양불사성보조항결핵약물치료，대조조환자여이상규항결핵약물치료。관찰량조환자치료3、6、12개월급치료후1개월담균전음정황、영상학료효（결핵조개선료효、폐공동개선료효）급불량반응（위장도반응、간공능경도수손、신공능경도수손、두훈핍력）발생정황。결과연구조환자치료3개월급치료후1개월담균전음솔고우대조조，차이유통계학의의（P ﹤0.05）；량조환자치료6、12개월담균전음솔비교，차이무통계학의의（ P ﹥0.05）；연구조환자결핵조개선료효화폐공동개선료효우우대조조，차이유통계학의의（ P ﹤0.05）；량조환자불량반응발생솔비교，차이무통계학의의（P ﹥0.05）。결론좌양불사성보조항결핵약물치료내다약폐결핵적림상료효현저，가유효살멸결핵간균，차불량반응소。
Objective To explore the effect of levofloxacin auxiliary of antitubercular agents in treating multi - drug resistant pulmonary tuberculosis. Methods A total of 140 patients with multi - drug resistant pulmonary tuberculosis were se-lected in the Fourth People's Hospital of Panzhihua from March 2010 to August 2013,they were randomly divided into study group and control group,70 cases in each group. Study group were given levofloxacin auxiliary of antitubercular agents treatment, control group were given conventional antitubercular agents treatment. Treatment for 3,6,12 months and 1 month after treat-ment,sputum became negative rate,imaging effect(tuberculous foci improve efficacy,lung cavity improve efficacy)and inci-dence of adverse reactions( gastrointestinal reaction,liver function damage,renal function damage,dizziness and hypody-namia)between the two groups were observed. Results Treatment for 3 months and 1 month after treatment,sputum became negative rate of study group were higher than those of control group(P ﹤ 0. 05);treatment for 6 ,12 months,tsputum became negative rate showed no significant differences between the two groups(P ﹥ 0. 05);tuberculous foci improve efficacy and lung cavity improve efficacy of study group were better than those of control group(P ﹤ 0. 05);incidence of adverse reactions showed no significant differences between the two groups(P ﹥ 0. 05). Conclusion Levofloxacin auxiliary of antitubercular agents have notable curative effect in the treatment of multi - drug resistant pulmonary,can effectively kill mycobacterium tuberculosis and has less adverse reactions.
