CAJ | 학술논문

[目的]总结哮喘发病机理中白三烯及其受体作用的最新研究情况。[方法]查阅近5年CNKI、维普数据、PUBMED数据中以白三烯及哮喘为关键词的研究文献，并分别从白三烯、白三烯受体拮抗剂与哮喘的关系，及中药对哮喘中白三烯的影响几个方面进行分类、汇总。[结果]大量临床研究、动物体内及体外实验表明，白三烯及其受体在多细胞、多环节中参与哮喘发病及进展，并与多种细胞因子相互影响。白三烯在哮喘及其他炎症疾病发病机理中起到重要作用，可以调节免疫应答。[结论]以“整体性”为特征的“组学”技术，更适合成为主要手段应用在具有整体观念的中医药研究领域，为中医药领域研究药物调控白三烯途径及治疗哮喘提供新观点。
[목적]총결효천발병궤리중백삼희급기수체작용적최신연구정황。[방법]사열근5년CNKI、유보수거、PUBMED수거중이백삼희급효천위관건사적연구문헌，병분별종백삼희、백삼희수체길항제여효천적관계，급중약대효천중백삼희적영향궤개방면진행분류、회총。[결과]대량림상연구、동물체내급체외실험표명，백삼희급기수체재다세포、다배절중삼여효천발병급진전，병여다충세포인자상호영향。백삼희재효천급기타염증질병발병궤리중기도중요작용，가이조절면역응답。[결론]이“정체성”위특정적“조학”기술，경괄합성위주요수단응용재구유정체관념적중의약연구영역，위중의약영역연구약물조공백삼희도경급치료효천제공신관점。
Objective] Summarize the pathogenesis of asthma and leukotriene receptor in latest research situation. [Methods]Check out the past five years CNKI, VIP data, PUBMED data to leukotrienes and asthma for keyword research literature, and classification, summary. [Results]Numerous clinical studies, in vivo and in vitro experiments showed that leukotrienes and their receptors are involved in the pathogenesis of asthma and progress in a multi-cell, multi-session, and interact with a variety of cytokines.[Conclusion]With "concept of wholism" as the characteristics of the "Genomics" technologies, more suitable as a primary means of application in the field of medical research has an overall concept for the regulation of traditional Chinese medicine research in the field of drugs to treat asthma leukotriene pathway and provide a new perspective.