中国医学创新
中國醫學創新
중국의학창신
Medical Innovation of China
2015年
27期
40-41,42
,共3页
孔令军%刘诏薄%左小云%彭冬英
孔令軍%劉詔薄%左小雲%彭鼕英
공령군%류조박%좌소운%팽동영
帕罗西汀%奥氮平%强迫症
帕囉西汀%奧氮平%彊迫癥
파라서정%오담평%강박증
Paroxetine%Olanzapine%Obsessive-compulsive disorder
目的:观察帕罗西汀合并奥氮平治疗强迫症的临床效果和不良反应。方法:将80例强迫症患者随机分成两组,每组40例,研究组服用帕罗西汀和奥氮平,对照组单用帕罗西汀,疗程均为8周。采用汉密顿焦虑量表(HAMA)、耶鲁-布朗强迫症状量表(Y-BOCS)评定临床疗效,采用副反应量表(TESS)评定副反应。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗第8周时两组Y-BOCS、HAMA 评分比较差异有统计学意义(P<0.05)。两组TESS评分在治疗第1、2、4、8周末差异均无统计学意义(P>0.05)。结论:帕罗西汀合并奥氮平治疗强迫症可以提高疗效,安全性较好,不会明显增加不良反应。
目的:觀察帕囉西汀閤併奧氮平治療彊迫癥的臨床效果和不良反應。方法:將80例彊迫癥患者隨機分成兩組,每組40例,研究組服用帕囉西汀和奧氮平,對照組單用帕囉西汀,療程均為8週。採用漢密頓焦慮量錶(HAMA)、耶魯-佈朗彊迫癥狀量錶(Y-BOCS)評定臨床療效,採用副反應量錶(TESS)評定副反應。結果:研究組治療總有效率高于對照組,差異有統計學意義(P<0.05)。治療第8週時兩組Y-BOCS、HAMA 評分比較差異有統計學意義(P<0.05)。兩組TESS評分在治療第1、2、4、8週末差異均無統計學意義(P>0.05)。結論:帕囉西汀閤併奧氮平治療彊迫癥可以提高療效,安全性較好,不會明顯增加不良反應。
목적:관찰파라서정합병오담평치료강박증적림상효과화불량반응。방법:장80례강박증환자수궤분성량조,매조40례,연구조복용파라서정화오담평,대조조단용파라서정,료정균위8주。채용한밀돈초필량표(HAMA)、야로-포랑강박증상량표(Y-BOCS)평정림상료효,채용부반응량표(TESS)평정부반응。결과:연구조치료총유효솔고우대조조,차이유통계학의의(P<0.05)。치료제8주시량조Y-BOCS、HAMA 평분비교차이유통계학의의(P<0.05)。량조TESS평분재치료제1、2、4、8주말차이균무통계학의의(P>0.05)。결론:파라서정합병오담평치료강박증가이제고료효,안전성교호,불회명현증가불량반응。
Objective:To evaluate the clinical efficiency of Paroxetine combined with Olanzapine in treating obsessive-compulsive disorder.Method:80 patients with obsessive-compulsive disorder were randomly divided into study group and control group,40 cases in each group. Paroxetine and Olanzapine were given to the study group,while only paroxetine was given to the control group,the treatment course were 8 weeks.Yale-Brown obsessive compulsive scale (Y-BOCS),Hamilton anxiety scale(HAMA) were used before treatment and after 8 weeks treatment to assess the efficacy,treatment emergent symptom scale (TESS) was used to assess the side effects.Result:The total effective rate of observation group was higher than that of control group,the difference was significant (P<0.05),while after 8 weeks treatment,Y-BOCS,HAMA scores between the two groups had significant difference(P<0.05).While after 1,2,4, 8 weeks treatment,TESS scores between the two groups had no significant difference(P>0.05).Conclusion:Paroxetine combined with Olanzapine in treatment of obsessive-compulsive disorder can improve therapeutic efficacy,the security is better,not increase adverse reactions.