CAJ | 학술논문

目的：观察中药加味抑肝汤治疗抑郁症的临床疗效和不良反应。方法：采用随机对照试验，共纳入治疗组（加味抑肝汤）46例，对照组（百忧解）46例，于用药前及用药后第1、2、4、6周分别以汉密尔顿抑郁量表（24项，HAMD）评定药物疗效，用描述性记录不良反应。结果治疗6周后，治疗组和对照组有效率分别为76.1%和73.9%，差异无统计学意义（P＞0.05）；HAMD减分率治疗组与对照组差异无统计学意义（P＞0.05）。不良反应发生率治疗组和对照组分别为15.2%和47.8%，差异具有统计学意义（P＜0.01）。结论：加味抑肝汤治疗抑郁症与百忧解疗效相当，不良反应明显少于百忧解。
목적：관찰중약가미억간탕치료억욱증적림상료효화불량반응。방법：채용수궤대조시험，공납입치료조（가미억간탕）46례，대조조（백우해）46례，우용약전급용약후제1、2、4、6주분별이한밀이돈억욱량표（24항，HAMD）평정약물료효，용묘술성기록불량반응。결과치료6주후，치료조화대조조유효솔분별위76.1%화73.9%，차이무통계학의의（P＞0.05）；HAMD감분솔치료조여대조조차이무통계학의의（P＞0.05）。불량반응발생솔치료조화대조조분별위15.2%화47.8%，차이구유통계학의의（P＜0.01）。결론：가미억간탕치료억욱증여백우해료효상당，불량반응명현소우백우해。
Objective To observe clinical efficacy and adverse reaction(ADR) of the Jiawei Yigan decoction on depression. Methods: patients were divided into two groups randomly: 46 cases in treatment group(Jiawei Yigan Decoction) and 46 cases in control group(Fluoxetine), Hamilton Depression scale(24 Items, HAMD) was used to evaluate the drug effect, and the score was recorded at pre-drug treatment and 1, 2, 4, 6 weeks post-drug treatment. The discription of ADR was recorded in time. Results: After 6 weeks of treatment, the efficacy was 76.1% and 73.9% in treatment and control group respectively. There was no significant difference between two groups at efficiency (P>0.05), as well as at decreasing of HAMD(P>0.05). The incidence of ADR was 15.2% and 47.8%, respectively, there was statistical difference between two groups(P<0.05). Conclusion: The Jiawei Yigan Decoction show equivalent efficacy to Fluoxetine for despression, but causes less ADR.