CAJ | 학술논문

叉头盒蛋白A1(FOXA1)基因在人体许多组织如乳腺、肝、胰腺、膀胱、前列腺、结肠、卵巢、肺和食管中表达,其表达与这些器官的发育及这些器官的肿瘤发生密切相关.目前研究发现其在调节细胞增殖、分化、发育及肿瘤形成、上皮间质转化(EMT)等过程中起重要作用,其表达与与ER、PR呈正相关,是乳腺癌良好预后的重要预测因子之一.
차두합단백A1(FOXA1)기인재인체허다조직여유선、간、이선、방광、전렬선、결장、란소、폐화식관중표체,기표체여저사기관적발육급저사기관적종류발생밀절상관.목전연구발현기재조절세포증식、분화、발육급종류형성、상피간질전화(EMT)등과정중기중요작용,기표체여여ER、PR정정상관,시유선암량호예후적중요예측인자지일.
Forkhead box A1 (FOXA1) is expressed in various organs,including breast,liver,pancreas,bladder,prostate,colon,ovary,lung and esophagus.The FOXA1 expression is associated with the growth and carcinogenesis of these organs.It is recently demonstrated FOXA1 plays a significant role in different biological processes including cell proliferation,differentiation,devolopment,carcinogenesis and the process of epithelial-mesenchymal transition (EMT) etc.Its expression is positively correlated with ER and PR expression,and it is demonstrate to be one of the most important favorate prognostic factors of breast cancer.