CAJ | 학술논문

目的：探讨急性冠状动脉综合征患者 TIMI 危险评分与血浆 N 末端前脑利钠肽(NTpro-BNP)水平及血清肌钙蛋白Ⅰ(TNⅠ)的相关性。方法收集2013年5月至2014年9月在该院接受治疗的98例急性冠状动脉综合征患者,按照患者的临床指标对患者进行 TIMI 危险评分,根据评分将患者分为低危组(n=23)、中危组(n=34)、高危组(n=41),采用 AQT 快速免疫分析法检测患者血浆 NTpro-BNP 及 TNⅠ水平,研究 TIMI 危险评分、NTpro-BNP 及 TNⅠ的相关性。结果TIMI 评分在单支、双支、三支病变间差异有统计学意义(P <0.01)。临床上对于不同分型疾病的判断具有一致性,差异有统计学意义(P <0.01)。TIMI 危险评分能够有效预测患者的心血管不良事件发生情况,其中3组患者治疗后6个月均较3个月和治疗期的不良事件发生率高,高危组各个时期的不良事件发生率较低危和中危组高,差异有统计学意义(P <0.01)。低危、中危、高危组患者随着 TIMI危险评分的升高,NTpro-BNP 和 BNP 水平均升高,NTpro-BNP 升高更加显著(P <0.01)。Spearman 等级相关分析可知,NTpro-BNP 与 TIMI 呈正相关(P <0.01),与 TNⅠ呈正相关(P <0.05)；TIMI 与 TNⅠ相关性差异无统计学意义(P >0.01)。结论急性冠脉综合征患者 TIMI 危险评分与 NTpro-BNP 相关性良好,而且与 TNⅠ无相关性。
목적：탐토급성관상동맥종합정환자 TIMI 위험평분여혈장 N 말단전뇌리납태(NTpro-BNP)수평급혈청기개단백Ⅰ(TNⅠ)적상관성。방법수집2013년5월지2014년9월재해원접수치료적98례급성관상동맥종합정환자,안조환자적림상지표대환자진행 TIMI 위험평분,근거평분장환자분위저위조(n=23)、중위조(n=34)、고위조(n=41),채용 AQT 쾌속면역분석법검측환자혈장 NTpro-BNP 급 TNⅠ수평,연구 TIMI 위험평분、NTpro-BNP 급 TNⅠ적상관성。결과TIMI 평분재단지、쌍지、삼지병변간차이유통계학의의(P <0.01)。림상상대우불동분형질병적판단구유일치성,차이유통계학의의(P <0.01)。TIMI 위험평분능구유효예측환자적심혈관불량사건발생정황,기중3조환자치료후6개월균교3개월화치료기적불량사건발생솔고,고위조각개시기적불량사건발생솔교저위화중위조고,차이유통계학의의(P <0.01)。저위、중위、고위조환자수착 TIMI위험평분적승고,NTpro-BNP 화 BNP 수평균승고,NTpro-BNP 승고경가현저(P <0.01)。Spearman 등급상관분석가지,NTpro-BNP 여 TIMI 정정상관(P <0.01),여 TNⅠ정정상관(P <0.05)；TIMI 여 TNⅠ상관성차이무통계학의의(P >0.01)。결론급성관맥종합정환자 TIMI 위험평분여 NTpro-BNP 상관성량호,이차여 TNⅠ무상관성。
Objective To discuss the correlation TIMI risk score to plasma N terminal pro brain natriuretic peptide(NTpro-BNP)level and serum troponin Ⅰ(TNⅠ)in patients with acute coronary syndrome.Methods Totally 98 cases of acute coronary artery from May,2013 to September,2014 treated in our hospital with syndrome TIMI risk score were observed,According to the score,the patients were divided into low risk group(n=23),middle risk group(n=34)and high risk group(n=41),and NTpro-BNP and TNⅠ levels were detected by AQT rapid immunoassay.The correlation of TIMI and NTpro-BNP and TNⅠ were stud-ied..Results TIMI scores in single,double,triple disease have statistically significant differences(P <0.01).The adverse event in-cidence of the high risk group was higher than the middle risk group and the low risk group(P <0.01).TIMI risk score was effec-tive in predicting adverse cardiovascular events,patients in the 3 groups after 6 months of treatment all had higher incidence of ad-verse events than that of the 3 month and the treatment period,the incidence of adverse events in high risk group was significantly higher than that in low risk group and middle risk group(P <0.01).Low risk group,the middle group,the high risk group of pa-tients with the increase of TIMI risk score,NTpro-BNP and BNP levels were elevated,NTpro-BNP increases more significantly,can be used to identify high risk patients,(P <0.01).Spearman rank correlation analysis shows that NTpro-BNP was relation to TIMI (P <0.01),and NTpro-BNP had positive correlation with TNⅠ(P <0.05);TIMI no statistically significant correlation with TNⅠ(P >0.01).Conclusion TIMI risk score in patients with acute coronary syndromes has significant correlation with NTpro-BNP, but has no correlation with TNⅠ.