CAJ | 학술논문

目的：分析该地区泌尿生殖道支原体感染及耐药状况,为临床合理用药提供依据。方法采用支原体培养、鉴定、药敏试剂盒对19530例泌尿生殖道感染患者的送检标本进行检测,分析支原体感染及药敏情况。结果19530例送检样本中,支原体阳性11178例,阳性率为57.24%,其中解脲支原体(Uu)、人型支原体(Mh)、Uu+Mh 混合感染阳性率分别为44.63%、0.44%和12.17%；女性支原体阳性率高于男性,差异有统计学意义(P <0.05)；2008~2014年支原体阳性率呈上升趋势；支原体对交沙霉素、强力霉素、米诺环素、克拉霉素敏感率分别为88.57%、84.32%、76.09%、71.53%,对喹诺酮类抗菌药物耐药率高；Uu、Mh 和 Uu+Mh 3类感染对12种抗菌药物的耐药种数递增。结论泌尿生殖道感染以 Uu 感染为主,Mh 感染多以混合感染方式出现；交沙霉素、强力霉素是该地区治疗支原体的首选药物,临床可参考药敏结果合理用药。支原体多重耐药情况严重,应引起临床重视。
목적：분석해지구비뇨생식도지원체감염급내약상황,위림상합리용약제공의거。방법채용지원체배양、감정、약민시제합대19530례비뇨생식도감염환자적송검표본진행검측,분석지원체감염급약민정황。결과19530례송검양본중,지원체양성11178례,양성솔위57.24%,기중해뇨지원체(Uu)、인형지원체(Mh)、Uu+Mh 혼합감염양성솔분별위44.63%、0.44%화12.17%；녀성지원체양성솔고우남성,차이유통계학의의(P <0.05)；2008~2014년지원체양성솔정상승추세；지원체대교사매소、강력매소、미낙배소、극랍매소민감솔분별위88.57%、84.32%、76.09%、71.53%,대규낙동류항균약물내약솔고；Uu、Mh 화 Uu+Mh 3류감염대12충항균약물적내약충수체증。결론비뇨생식도감염이 Uu 감염위주,Mh 감염다이혼합감염방식출현；교사매소、강력매소시해지구치료지원체적수선약물,림상가삼고약민결과합리용약。지원체다중내약정황엄중,응인기림상중시。
Objective To analyze the status of mycoplasma infection and drug resistance in the local area,and provide the ba-sis for clinical rational drug use.Methods The specimens obtained from 1 9 530 patients with urogenital tract infection were detec-ted by adopting mycoplasma culture,identification and drug sensitivity integration kit.Mycoplasma infection and drug susceptibility were analyzed.Results In the total of 1 9 530 suspected patients specimens,1 1 1 78 cases were positive with a positive rate 57.24%.The positive rate of ureaplasma urealyticum (Uu)and mycoplasma hominis (MH)was 44.63% and 0.44% respectively and the positive rate of Uu and Mh mixed infection was 12.1 7%.The positive rate of female was higher than that of male and the difference was statistically significant(P <0.05).The positive rate of mycoplasma in 2008-2014 was on the rise;The sensitive rate of mycoplasma to josamycin,doxycycline,minocycline element,clarithromycin was 88.57%,84.32%,76.09% and 71.53% respec-tively,mycoplasma was highly drug resistance to quinolone antibiotics;mixed infection resistance was higher than that of single in-fection;The number of drug resistance of Uu,MH and Uu+MH to 12 kinds of antibiotics increase.Conclusion Mycoplasma infec-tion in urogenital tract is mainly caused by Uu and Mh infection is in mixed infection way;josamycin,doxycycline is the first choice for treatment of mycoplasma in this region.Rational drug choise can be based on the drug susceptibility test.Multiple drug resist-ance of mycoplasma is serious and should be paid attention to.