CAJ | 학술논문

目的：通过测定植入起搏器患者术前、术后6个月血浆NT-proBNP水平，以研究不同起搏模式及起搏比例对患者血浆NT-proBNP水平的影响。方法选择接受起搏治疗的68例患者，其中AAI(R)模式12例，VVI(R)模式32例，DDD(R)模式24例，分别于起搏器植入术前、术后6个月测定血浆NT-proBNP水平，通过起搏器程控仪获得患者术后6个月的心房、心室起搏比例。结果3种起搏模式下患者术后6个月血浆NT-proBNP均有不同程度升高，其中VVI(R)起搏术前及术后6个月组内比较及与AAI(R)、DDD(R)起搏术后6个月NT-proBNP水平组间比较，差异有显著性(P<0.05)，亚组分析显示VVI (R)、DDD(R)模式下，心室起搏比例>50%组与起搏比例<50%组比较，血浆NT-proBNP水平差异有显著性(P<0.05)。结论 VVI (R)起搏模式及较高的心室起搏比例能引起血浆NT-proBNP水平显著变化，对房室传导功能正常的患者，应优先选择AAI(R)或DDD(R)起搏模式。
목적：통과측정식입기박기환자술전、술후6개월혈장NT-proBNP수평，이연구불동기박모식급기박비례대환자혈장NT-proBNP수평적영향。방법선택접수기박치료적68례환자，기중AAI(R)모식12례，VVI(R)모식32례，DDD(R)모식24례，분별우기박기식입술전、술후6개월측정혈장NT-proBNP수평，통과기박기정공의획득환자술후6개월적심방、심실기박비례。결과3충기박모식하환자술후6개월혈장NT-proBNP균유불동정도승고，기중VVI(R)기박술전급술후6개월조내비교급여AAI(R)、DDD(R)기박술후6개월NT-proBNP수평조간비교，차이유현저성(P<0.05)，아조분석현시VVI (R)、DDD(R)모식하，심실기박비례>50%조여기박비례<50%조비교，혈장NT-proBNP수평차이유현저성(P<0.05)。결론 VVI (R)기박모식급교고적심실기박비례능인기혈장NT-proBNP수평현저변화，대방실전도공능정상적환자，응우선선택AAI(R)혹DDD(R)기박모식。
Objective To observe changes of blood N-terminal precursor of B-type natriuretic peptide (NT-proBNP) in pa-tients with different pacing mode and ratio of heart Beats by Pacemaker. Methods We assayed NT-proBNP levels before opera-tions and 6 months postoperatively. NT-proBNP level changes were compared in different pacing mode and pacing ratio. We col-lected 68 patients with implantable of permanent pacemaker. 12 subjects with AAI (R) mode,24 subjects with DDD (R) mode,32 subjects with VVI (R)mode. We measured plasma NT-proBNP levels before operations and 6 months postoperatively. The ratio of heart beats by Pacemaker were acquired by pacemaker programmer. Results The plasma NT-proBNP level was arised among the three pacing modes to some extent. Compared with DDD (R) mode and AAI (R) mode after 6 months of post-operation ,The NT-proBNP level changes of the group (DDDR mode) were significant. The sub-group analysis indicated that NT-proBNP level changes were remarkable between the ventricular pacing ratio>50%or not. Conclusion The NT-proBNP level changes were sig-nificant with the VVI (R) pacing mode or high ventriculau pacing ratio,and AAI (R) or DDD (R) is the better pacing mode if pa-tients′atrioventricular conduction function is normal.