CAJ | 학술논문

目的：观察甘氨双唑钠放疗增敏在乳腺癌脑转移患者治疗中的疗效和毒副反应。方法36例乳腺癌脑转移患者中16例行甘氨双唑钠增敏放疗，20例行单纯放疗。放疗方案：DT40 Gy／20次或30 Gy／10次。放疗增敏组甘氨双唑钠800 mg／m2，每周3次。比较两组近期疗效、颅内中位无进展生存期（ PFS）及毒副反应。结果甘氨双唑钠放疗增敏组的有效率为87?5％，单纯放疗组为50?0％，差异有统计学意义（ P＜0?05）。放疗增敏组颅内中位PFS为9?9个月，单纯放疗组为5?3个月，差异有统计学意义（ P＜0?05）。两组毒副反应主要为脱发、头痛、恶心呕吐和白细胞减少，均为1～2级，差异无统计学意义（ P＞0?05）。结论甘氨双唑钠放疗增敏治疗乳腺癌脑转移具有较好的疗效，且不增加毒副反应。
목적：관찰감안쌍서납방료증민재유선암뇌전이환자치료중적료효화독부반응。방법36례유선암뇌전이환자중16례행감안쌍서납증민방료，20례행단순방료。방료방안：DT40 Gy／20차혹30 Gy／10차。방료증민조감안쌍서납800 mg／m2，매주3차。비교량조근기료효、로내중위무진전생존기（ PFS）급독부반응。결과감안쌍서납방료증민조적유효솔위87?5％，단순방료조위50?0％，차이유통계학의의（ P＜0?05）。방료증민조로내중위PFS위9?9개월，단순방료조위5?3개월，차이유통계학의의（ P＜0?05）。량조독부반응주요위탈발、두통、악심구토화백세포감소，균위1～2급，차이무통계학의의（ P＞0?05）。결론감안쌍서납방료증민치료유선암뇌전이구유교호적료효，차불증가독부반응。
Objective To observe the efficacy and safety of sodium glycididazole( CMNa) in combination with radiotherapy on breast cancer with brain metastasis. Methods Thirty?six breast cancer patients with brain metastasis were enrolled in this study. Sixteen patients were treated with CMNa+radiotherapy(CMNa group), and 20 patients were treated with radiotherapy alone(radiation group) . The total dosage of radiation was 40 Gy/20 f,or 30 Gy/10 f. CMNa was taken 800 mg/m2 three times a week. The response rate( RR) , median intracranial progression?free survival ( PFS) and side effects were analyzed. Results The RR of CMNa group was 87?5%, and 50?0% in radiation group,with significant differences(P<0?05). The median intracranial PFS of CMNa group was 9?9 months,and 5?3 months in radiation group,with significant differences(P<0?05).The main side effects of the two groups were hair loss, headache, nausea/vomitting and leukopenia of grade 1?2 ( P>0?05) . Conclusion CMNa in combination with radiotherapy is a feasible and effective treatment for breast cancer with brain metastasis without increase in side effects.