CAJ | 학술논문

目的：探讨瞬时受体电位离子通道(TRPM7)在胆管癌组织中的表达及其与预后的相关性。方法应用免疫组织化学 SP 法检测 TRPM7在49例胆管癌、7例胆管良性病变组织和36例癌旁正常胆管组织的表达情况,分析其与胆管癌临床病理的关系。结果胆管癌组织中 TRPM7表达阳性率为77.6%(38/49),高于其在胆管良性病变组织的表达阳性率(0,0/7)及癌旁正常胆管组织中的表达阳性率(2.8%,1/36),差异均有统计学意义(P <0.05)。TRPM7蛋白的表达与胆管癌的 TNM 分期、淋巴结转移和脏器转移相关(P <0.05),但与患者的年龄、性别、部位、肿瘤分化程度及肝炎无相关性(P >0.05)。Kaplan-Meier 生存分析发现 TRPM7阳性表达患者的生存期低于 TRPM7阴性表达患者(P <0.05)。Cox 多因素分析显示,TRPM7的表达水平与生存预后显著相关(P <0.05),是影响预后的独立危险因素。结论TRPM7在胆管癌的发生、发展和浸润转移中发挥着重要作用,是影响胆管癌患者预后的重要因素。
목적：탐토순시수체전위리자통도(TRPM7)재담관암조직중적표체급기여예후적상관성。방법응용면역조직화학 SP 법검측 TRPM7재49례담관암、7례담관량성병변조직화36례암방정상담관조직적표체정황,분석기여담관암림상병리적관계。결과담관암조직중 TRPM7표체양성솔위77.6%(38/49),고우기재담관량성병변조직적표체양성솔(0,0/7)급암방정상담관조직중적표체양성솔(2.8%,1/36),차이균유통계학의의(P <0.05)。TRPM7단백적표체여담관암적 TNM 분기、림파결전이화장기전이상관(P <0.05),단여환자적년령、성별、부위、종류분화정도급간염무상관성(P >0.05)。Kaplan-Meier 생존분석발현 TRPM7양성표체환자적생존기저우 TRPM7음성표체환자(P <0.05)。Cox 다인소분석현시,TRPM7적표체수평여생존예후현저상관(P <0.05),시영향예후적독립위험인소。결론TRPM7재담관암적발생、발전화침윤전이중발휘착중요작용,시영향담관암환자예후적중요인소。
Objective To evaluate the expression of transient receptor potential melastatin 7(TRPM7)in cholangiocarcinoma and its correlation with prognosis.Methods The expressions of TRPM7 were detected by SP immunohistochemical in 49 cases of cholangiocarcinoma,7 cases of benign bile duct lesions and 36 cases of adjacent histologically noncancerous bile duct tissues,and to analysis its relationship with the clinical pathological characteristics of cholangiocarcinoma.Results The positive expression rate of TRPM7 in cholangiocarcinoma was 77.6%(38/49),which was higher than that in benign bile duct lesions(0,0/7)and adjacent his-tologically noncancerous bile duct tissues(2.8%,1/36),the difference was statistically significant(P <0.05).The positive expres-sion of TRPM7 in cholangiocarcinoma was correlated with the TNM stage of tumor,lymph node metastasis and organ metastasis (P <0.05),but not related to patients′age,gender,site,differentiation and hepatitis(P >0.05).Kaplan-Meier analysis showed that increased expression of TRPM7 was associated with shorted overall survival (P <0.05).Cox regression analysis showed that the expression level of TRPM7 was significantly associated with prognosis and an independent risk factor for prognosis(P <0.05 ). Conclusion TRPM7 plays an important role in the tumorigenesis progression,invasion,and metastasis of cholangiocarcinoma,and is an important factor for prognosis in patients with cholangiocarcinoma.