CAJ | 학술논문

目的：探讨2型糖尿病患者糖化血红蛋白及中心动脉压与颈动脉斑块形成的相关性。方法测定糖尿病组（120例）、正常对照组（100例）的糖化血红蛋白，平均空腹血糖及外周血压、中心动脉压（包括中心收缩压、中心舒张压和中心脉压）。再根据彩超结果分斑块组和非斑块组、测定上述指标。并进行统计学分析。结果（1）糖化血红蛋白、平均空腹血糖浓度比较，糖尿病组显著高于正常对照组。（2）中心收缩压和中心脉压数值上，糖尿病组与正常对照组无明显差异。（3）颈动脉斑块组的糖化血红蛋白、平均空腹血糖浓度及中心收缩压、中心脉压水平均显著高于无颈动脉斑块组（P＜0．05）。（4）糖尿病组糖化血红蛋白水平与颈动脉斑块发生率呈正相关。（5）多元线性回归分析表明2型糖尿病患者中糖化血红蛋白、中心收缩压、中心脉压是颈动脉斑块发生发展的危险因素。结论2型糖尿病患者测定糖化血红蛋白、中心收缩压、中心脉压有助于监控糖尿病合并颈动脉斑块的发生发展。
목적：탐토2형당뇨병환자당화혈홍단백급중심동맥압여경동맥반괴형성적상관성。방법측정당뇨병조（120례）、정상대조조（100례）적당화혈홍단백，평균공복혈당급외주혈압、중심동맥압（포괄중심수축압、중심서장압화중심맥압）。재근거채초결과분반괴조화비반괴조、측정상술지표。병진행통계학분석。결과（1）당화혈홍단백、평균공복혈당농도비교，당뇨병조현저고우정상대조조。（2）중심수축압화중심맥압수치상，당뇨병조여정상대조조무명현차이。（3）경동맥반괴조적당화혈홍단백、평균공복혈당농도급중심수축압、중심맥압수평균현저고우무경동맥반괴조（P＜0．05）。（4）당뇨병조당화혈홍단백수평여경동맥반괴발생솔정정상관。（5）다원선성회귀분석표명2형당뇨병환자중당화혈홍단백、중심수축압、중심맥압시경동맥반괴발생발전적위험인소。결론2형당뇨병환자측정당화혈홍단백、중심수축압、중심맥압유조우감공당뇨병합병경동맥반괴적발생발전。
Objective To study the correlation between glycosylated hemoglobin ,central aortic pressure and the formation of the carotid artery plaque with the patients of type 2 diabetes mellitus .Methods Determi-nating the glycosylated hemoglobin ,average fasting blood glucose and peripheral blood pressure ,central aortic pressure( including central systolic pressure ,diastolic pressure ,central pulse pressure) ,of 120 diabetes mellitus patients (diabetes mellitus group) and 100 healthy volunteers (normal control group) .Then according to the re-sult of ultrasound ,the patients were divided into carotid artery plaque group and non -plaque group ,all the data were determined again ,the correlation between glycosylated hemoglobin ,central aortic pressure and the forma-tion of the carotid artery plaque was analyzed by SPSS .Results (1 ) The glycosylated hemoglobin ,average fast-ing blood glucose levels of diabetes group are significantly higher than those of normal control group .(2 )There is no significant difference between systolic central aortic pressure and central pulse pressure of the diabetes mellitus group and those of normal control group .(3 )Glycosylated hemoglobin ,average fasting blood glucose ,central pulse pressure ,systolic central aortic pressure of carotid artery plaque group levels were significantly higher than those of non-plaque group( P<0 .0 1 ) .(4 )Glycosylated hemoglobin levels and the incidence of carotid plaques were positively correlated in diabetes group .(5 )Multiple linear regression analysis showed that for the patients of type 2 diabetes ,glycosylated hemoglobin ,central systolic pressure and central pulse pressure is risk factors of oc-currence and development of carotid plaques .Conclusion Concentrating glycosylated hemoglobin ,central sys-tolic pressure the central pulse pressure helps to monitor the occurrence and development of diabetic carotid plaques .