中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
Chinese Journal of Gastrointestinal Surgery
2015年
9期
925-929
,共5页
韦烨%林奇%汤文涛%许平平%许剑民
韋燁%林奇%湯文濤%許平平%許劍民
위엽%림기%탕문도%허평평%허검민
结直肠肿瘤%肝转移%同期切除%并发症%预后
結直腸腫瘤%肝轉移%同期切除%併髮癥%預後
결직장종류%간전이%동기절제%병발증%예후
Colorectal neoplasms%Liver metastasis%Simultaneous resection%Complications%Prognosis
目的:探讨同期手术切除结直肠癌肝转移的长期疗效及其影响因素。方法回顾性分析2003年7月至2013年7月间于上海复旦大学附属中山医院行同期切除的154例同时性结直肠癌肝转移患者的临床资料。观察患者术后的短期和长期疗效,并对可能影响预后的因素进行多因素Cox回归分析。结果全组无围手术期死亡病例,术后并发症发生率为29.9%(46/154),均经胸腹腔引流和抗感染支持治疗等非手术治疗措施获得治愈或明显缓解。全组5年总生存率为46%,5年无瘤生存率为35%。多因素分析显示,淋巴结阳性(P=0.000)、转移灶数大于或等于4个(P=0.017)、转移灶双叶分布(P=0.004)和切缘阳性(P=0.001)是总生存率低的独立预后因素;淋巴结阳性(P=0.031)、转移灶双叶分布(P=0.001)和合并肝外转移(P=0.020)是无瘤生存率低的独立预后因素。结论同期切除结直肠癌肝转移安全可行,长期生存也较佳。淋巴结阳性、转移灶数4个以上、转移灶双叶分布、切缘阳性及肝外转移可作为长期预后较差的预测参考。
目的:探討同期手術切除結直腸癌肝轉移的長期療效及其影響因素。方法迴顧性分析2003年7月至2013年7月間于上海複旦大學附屬中山醫院行同期切除的154例同時性結直腸癌肝轉移患者的臨床資料。觀察患者術後的短期和長期療效,併對可能影響預後的因素進行多因素Cox迴歸分析。結果全組無圍手術期死亡病例,術後併髮癥髮生率為29.9%(46/154),均經胸腹腔引流和抗感染支持治療等非手術治療措施穫得治愈或明顯緩解。全組5年總生存率為46%,5年無瘤生存率為35%。多因素分析顯示,淋巴結暘性(P=0.000)、轉移竈數大于或等于4箇(P=0.017)、轉移竈雙葉分佈(P=0.004)和切緣暘性(P=0.001)是總生存率低的獨立預後因素;淋巴結暘性(P=0.031)、轉移竈雙葉分佈(P=0.001)和閤併肝外轉移(P=0.020)是無瘤生存率低的獨立預後因素。結論同期切除結直腸癌肝轉移安全可行,長期生存也較佳。淋巴結暘性、轉移竈數4箇以上、轉移竈雙葉分佈、切緣暘性及肝外轉移可作為長期預後較差的預測參攷。
목적:탐토동기수술절제결직장암간전이적장기료효급기영향인소。방법회고성분석2003년7월지2013년7월간우상해복단대학부속중산의원행동기절제적154례동시성결직장암간전이환자적림상자료。관찰환자술후적단기화장기료효,병대가능영향예후적인소진행다인소Cox회귀분석。결과전조무위수술기사망병례,술후병발증발생솔위29.9%(46/154),균경흉복강인류화항감염지지치료등비수술치료조시획득치유혹명현완해。전조5년총생존솔위46%,5년무류생존솔위35%。다인소분석현시,림파결양성(P=0.000)、전이조수대우혹등우4개(P=0.017)、전이조쌍협분포(P=0.004)화절연양성(P=0.001)시총생존솔저적독립예후인소;림파결양성(P=0.031)、전이조쌍협분포(P=0.001)화합병간외전이(P=0.020)시무류생존솔저적독립예후인소。결론동기절제결직장암간전이안전가행,장기생존야교가。림파결양성、전이조수4개이상、전이조쌍협분포、절연양성급간외전이가작위장기예후교차적예측삼고。
Objective To analyze long-term outcomes and related risk factors in patients undergoing simultaneous resection of synchronous colorectal liver metastasis. Methods Clinicopathological, short- and long-term outcome data of 154 consecutive synchronous colorectal liver metastasis patients who underwent simultaneous resection between July 2003 and July 2013 were collected and analyzed with Cox multivariate methods retrospectively. Results No perioperative death was found. A total of 46 patients ( 29 . 9%) had complications , which were all successfully treated medically or by percutaneous drainage. The 5-year overall survival rate was 46%, and the 5-year disease-free survival rate was 35%. Four factors were found to be independent predictors of poor overall survival by multivariate analysis:positive lymph node status(P=0.000), number of metastasis focus (≥4)(P=0.017), bilobar liver metastasis distribution (P=0.004) and non-R0 resection of liver metastasis (P=0.001). Three factors were found to be independent predictors of poor disease-free survival by multivariate analysis:positive lymph node status (P=0.031), bilobar liver metastasis distribution (P=0.001) and extrahepatic metastases (P=0.020). Conclusions Simultaneous resection of synchronous colorectal liver metastasis is safe and its short- and long-term outcomes are quite good. Positive lymph node status , number of metastasis focus (≥4), bilobar liver metastasis distribution, non-R0 resection of liver metastasis and extrahepatic metastasis are risk factors of poor long-term prognosis.