南京中医药大学学报
南京中醫藥大學學報
남경중의약대학학보
Journal of Nanjing University of Traditional Chinese Medicine
2015年
5期
424-427
,共4页
王丽娟%余江毅%罗玫%范丽萍
王麗娟%餘江毅%囉玫%範麗萍
왕려연%여강의%라매%범려평
临床期糖尿病肾病%火把花根片%厄贝沙坦胶囊%血清 HGF
臨床期糖尿病腎病%火把花根片%阨貝沙坦膠囊%血清 HGF
림상기당뇨병신병%화파화근편%액패사탄효낭%혈청 HGF
diabetic nephropathy in clinical stage%Huobahuagen tablets%Irbesartan capsule%serum HGF
目的:观察火把花根片干预临床期糖尿病肾病的近期疗效及对血清 HGF 的影响。方法将临床期 DN 患者分为治疗组(火把花根片联合厄贝沙坦胶囊)及对照组(厄贝沙坦胶囊),每组各30例。对照组给予厄贝沙坦胶囊每次150mg,每日1次,早晨空腹口服。治疗组在对照组的基础上加服火把花根片,每次3片,每日3次,早中晚饭后0.5 h 口服。测定2组治疗前后血糖(FPG、2 hPG、HbA1c)、血脂(TG、TC、LDL?C、HDL?C)、血 SCr、尿 ACR、UTP、血清肝细胞生长因子(HGF)水平。结果治疗后2组尿 ACR、UTP、SBP、DBP、血脂、SCr 较治疗前均有所下降(P <0.05~0.01),且治疗组治疗后尿 ACR、UTP、SBP、血脂、SCr 下降幅度明显优于对照组(P <0.05~0.01),总有效率治疗组(83.3%)优于对照组(40.0%),P <0.01。同时,2组 HGF 水平较治疗前均明显升高(P <0.01),治疗组优于对照组(P <0.01)。结论火把花根片可明显降低 SCr 水平及尿蛋白排泄率,提高血清 HGF 水平,可能延缓 DN 进展。
目的:觀察火把花根片榦預臨床期糖尿病腎病的近期療效及對血清 HGF 的影響。方法將臨床期 DN 患者分為治療組(火把花根片聯閤阨貝沙坦膠囊)及對照組(阨貝沙坦膠囊),每組各30例。對照組給予阨貝沙坦膠囊每次150mg,每日1次,早晨空腹口服。治療組在對照組的基礎上加服火把花根片,每次3片,每日3次,早中晚飯後0.5 h 口服。測定2組治療前後血糖(FPG、2 hPG、HbA1c)、血脂(TG、TC、LDL?C、HDL?C)、血 SCr、尿 ACR、UTP、血清肝細胞生長因子(HGF)水平。結果治療後2組尿 ACR、UTP、SBP、DBP、血脂、SCr 較治療前均有所下降(P <0.05~0.01),且治療組治療後尿 ACR、UTP、SBP、血脂、SCr 下降幅度明顯優于對照組(P <0.05~0.01),總有效率治療組(83.3%)優于對照組(40.0%),P <0.01。同時,2組 HGF 水平較治療前均明顯升高(P <0.01),治療組優于對照組(P <0.01)。結論火把花根片可明顯降低 SCr 水平及尿蛋白排洩率,提高血清 HGF 水平,可能延緩 DN 進展。
목적:관찰화파화근편간예림상기당뇨병신병적근기료효급대혈청 HGF 적영향。방법장림상기 DN 환자분위치료조(화파화근편연합액패사탄효낭)급대조조(액패사탄효낭),매조각30례。대조조급여액패사탄효낭매차150mg,매일1차,조신공복구복。치료조재대조조적기출상가복화파화근편,매차3편,매일3차,조중만반후0.5 h 구복。측정2조치료전후혈당(FPG、2 hPG、HbA1c)、혈지(TG、TC、LDL?C、HDL?C)、혈 SCr、뇨 ACR、UTP、혈청간세포생장인자(HGF)수평。결과치료후2조뇨 ACR、UTP、SBP、DBP、혈지、SCr 교치료전균유소하강(P <0.05~0.01),차치료조치료후뇨 ACR、UTP、SBP、혈지、SCr 하강폭도명현우우대조조(P <0.05~0.01),총유효솔치료조(83.3%)우우대조조(40.0%),P <0.01。동시,2조 HGF 수평교치료전균명현승고(P <0.01),치료조우우대조조(P <0.01)。결론화파화근편가명현강저 SCr 수평급뇨단백배설솔,제고혈청 HGF 수평,가능연완 DN 진전。
ABSTRACTOBJECTIVE To observe the treating effect of Huobahuagen tablets in intervening diabetic nephropathy in clinical stage and the influence on the level of serum HGF.METHODS DN patients in clinical stage were divided into two groupsthe treatment groupHuobahuagen tablets together with Irbesartan capsules and the control groupIrbesartan capsuleswith 30 cases in each group.The control group was given Irbesartan capsule150 mg every day in the morning for once and the pa-tients took it with an empty stomach.The treatment groupbesides taking the same medicine as prescribed for the control groupwas also given Huobahuagen tablets3 tablets a day for three times 0.5h after each meal.FPG2 hPGHbA1cTGTCLDL?CHDL?Cblood SCrurine ACRUTPHGF level were tested.RESULTS ACRUTPSBPDBPblood fatand SCr in both groups decreased after the treatmentP <0.05~0.01 and the decrease in the treatment group was sharper than that in the control groupP <0.05~0.01.The total effective rate in the treatment group was better in the treatment group83.3% vs 40%P <0.01.HGF levels in both group increased after the treatmentP <0.01.HGF level in the treat-ment group showed more increase compared with that of the control groupP <0.01.CONCLUSION Huobahuagen tablets can effectively lower the level of blood creatinine and the rate of urinary albumin excretionincrease the level of serum HGFand possibly slow down DN progression.