CAJ | 학술논문

目的：通过检测 Annexin A1在甲状腺乳头状癌中的表达,探讨其与甲状腺乳头状癌的关系与意义。方法取69例甲状腺乳头状癌患者癌组织及癌旁正常组织切片,使用二步法免疫组织化学染色观察 Annexin A1在甲状腺乳头状癌和癌旁正常组织中的表达情况。结果Annexin A1在癌组织中高表达。癌组织表达61例(88.41%),癌旁正常组织表达6例(8.69%),差异有统计学意义(P <0.05)；在淋巴结转移和肿瘤直径大于或等于1 cm 的患者中,Annexin A1表达高于肿瘤小于1 cm 的患者,差异有统计学意义(P <0.05)。结论甲状腺乳头状癌组织中 Annexin A1的高表达,提示其可能为甲状腺乳头状癌潜在的生物学标记物。
목적：통과검측 Annexin A1재갑상선유두상암중적표체,탐토기여갑상선유두상암적관계여의의。방법취69례갑상선유두상암환자암조직급암방정상조직절편,사용이보법면역조직화학염색관찰 Annexin A1재갑상선유두상암화암방정상조직중적표체정황。결과Annexin A1재암조직중고표체。암조직표체61례(88.41%),암방정상조직표체6례(8.69%),차이유통계학의의(P <0.05)；재림파결전이화종류직경대우혹등우1 cm 적환자중,Annexin A1표체고우종류소우1 cm 적환자,차이유통계학의의(P <0.05)。결론갑상선유두상암조직중 Annexin A1적고표체,제시기가능위갑상선유두상암잠재적생물학표기물。
Objective To explore the correlations between Annexin A1 protein expression and clinicopathological character-istics in carcinoma of papillary thyroid.Methods The different expressions of annexin A1 in papillary thyroid tissue and para-cari-noma tissue were investigated by immunohistochemistry.Results Among 69 samples tissues of papillary thyriod carcinoma,the positive rate of annexin A1 was higher than that of 69 para-carcinoma tissues(88.41%vs .8.69%),there was a significant difference (P <0.05).Furthermore,the expression of annexin A1 was correlation with the lymph node metastasis and tumor size,which was higher in ≥1 cm diameter of tumor(P <0.05).Conclusion High AnnexinA1 positive expression in papillary thyroid cancer tissues is associated with tumor malignant progression,which might be a valuable predictor and potential target for the diagnosis and treat-ment of papillary thyroid carcinoma.