中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
Chinese Journal of Gastrointestinal Surgery
2015年
9期
893-896
,共4页
张默言%臧若川%雷文东%薛奇%高树庚
張默言%臧若川%雷文東%薛奇%高樹庚
장묵언%장약천%뢰문동%설기%고수경
食管肿瘤%纤维膜%淋巴结转移%手术方式
食管腫瘤%纖維膜%淋巴結轉移%手術方式
식관종류%섬유막%림파결전이%수술방식
Esophageal neoplasms%Adventitia%Lymph node metastasis%Surgical procedures
目的:探讨局部侵犯未达纤维膜的食管鳞癌淋巴结转移规律及其危险因素,从而为食管癌手术方式的选择提供参考。方法回顾性分析2011年1月至2014年8月在中国医学科学院肿瘤医院行食管癌根治术且术后病理证实肿瘤未侵及纤维膜的484例食管癌患者的临床资料,总结不同部位食管癌的淋巴结转移规律,并对影响淋巴结转移的相关因素进行分析。结果全组患者淋巴结转移率为32.0%(155/484),其中胸上段、胸中段和胸下段食管癌的淋巴结转移率分别为26.2%(16/61)、27.4%(55/201)和37.8%(84/222)。在出现淋巴结转移的胸上段食管癌患者中,双侧喉返神经旁或气管食管沟区域淋巴结转移概率分别为43.8%(7/16)和37.5%(6/16);胸中段食管癌中右喉返神经旁、中段食管旁、下段食管旁及膈肌角淋巴结转移概率为25.5%(14/55)、29.1%(16/55)、36.4%(20/55)和36.4%(20/55);胸下段食管癌中中段食管旁、下段食管旁及膈肌角淋巴结转移概率为32.1%(27/84)、22.6%(19/84)和36.9%(31/84)。多因素分析显示,肿瘤最大径(P=0.005)、肿瘤分化程度(P=0.007)和肿瘤浸润深度(P=0.001)是未侵犯纤维膜的食管癌淋巴结转移的独立影响因素。结论不同部位食管鳞癌的淋巴结转移情况不同;肿瘤浸润深度、肿瘤大小及肿瘤分化程度均是未侵及纤维膜的食管癌发生淋巴结转移的危险因素。
目的:探討跼部侵犯未達纖維膜的食管鱗癌淋巴結轉移規律及其危險因素,從而為食管癌手術方式的選擇提供參攷。方法迴顧性分析2011年1月至2014年8月在中國醫學科學院腫瘤醫院行食管癌根治術且術後病理證實腫瘤未侵及纖維膜的484例食管癌患者的臨床資料,總結不同部位食管癌的淋巴結轉移規律,併對影響淋巴結轉移的相關因素進行分析。結果全組患者淋巴結轉移率為32.0%(155/484),其中胸上段、胸中段和胸下段食管癌的淋巴結轉移率分彆為26.2%(16/61)、27.4%(55/201)和37.8%(84/222)。在齣現淋巴結轉移的胸上段食管癌患者中,雙側喉返神經徬或氣管食管溝區域淋巴結轉移概率分彆為43.8%(7/16)和37.5%(6/16);胸中段食管癌中右喉返神經徬、中段食管徬、下段食管徬及膈肌角淋巴結轉移概率為25.5%(14/55)、29.1%(16/55)、36.4%(20/55)和36.4%(20/55);胸下段食管癌中中段食管徬、下段食管徬及膈肌角淋巴結轉移概率為32.1%(27/84)、22.6%(19/84)和36.9%(31/84)。多因素分析顯示,腫瘤最大徑(P=0.005)、腫瘤分化程度(P=0.007)和腫瘤浸潤深度(P=0.001)是未侵犯纖維膜的食管癌淋巴結轉移的獨立影響因素。結論不同部位食管鱗癌的淋巴結轉移情況不同;腫瘤浸潤深度、腫瘤大小及腫瘤分化程度均是未侵及纖維膜的食管癌髮生淋巴結轉移的危險因素。
목적:탐토국부침범미체섬유막적식관린암림파결전이규률급기위험인소,종이위식관암수술방식적선택제공삼고。방법회고성분석2011년1월지2014년8월재중국의학과학원종류의원행식관암근치술차술후병리증실종류미침급섬유막적484례식관암환자적림상자료,총결불동부위식관암적림파결전이규률,병대영향림파결전이적상관인소진행분석。결과전조환자림파결전이솔위32.0%(155/484),기중흉상단、흉중단화흉하단식관암적림파결전이솔분별위26.2%(16/61)、27.4%(55/201)화37.8%(84/222)。재출현림파결전이적흉상단식관암환자중,쌍측후반신경방혹기관식관구구역림파결전이개솔분별위43.8%(7/16)화37.5%(6/16);흉중단식관암중우후반신경방、중단식관방、하단식관방급격기각림파결전이개솔위25.5%(14/55)、29.1%(16/55)、36.4%(20/55)화36.4%(20/55);흉하단식관암중중단식관방、하단식관방급격기각림파결전이개솔위32.1%(27/84)、22.6%(19/84)화36.9%(31/84)。다인소분석현시,종류최대경(P=0.005)、종류분화정도(P=0.007)화종류침윤심도(P=0.001)시미침범섬유막적식관암림파결전이적독립영향인소。결론불동부위식관린암적림파결전이정황불동;종류침윤심도、종류대소급종류분화정도균시미침급섬유막적식관암발생림파결전이적위험인소。
Objective To explore the pattern of lymphatic metastasis and risk factors of esophageal carcinoma that invades less than adventitia. Methods Clinical data of 484 patients receiving esophagectomy from January 2011 to August 2014 were reviewed , whose carcinoma invaded less than adventitia. The lymph node metastasis pattern of the primary tumor and corresponding influence factor were analyzed. Results Total lymph node metastatic rate was 32.0%(155/484). Sixteen of 61 upper thoracic esophageal carcinoma patients (26.2%) had lymphatic metastasis. Fifty-five of 201 middle thoracic esophageal carcinoma patients (27.4%) had lymphatic metastasis. Eighty-four of 222 lower thoracic esophageal carcinoma patients (37.8%) had lymphatic metastasis. The deeper tumor invaded, the easier lymph node metastasis occurred, as well as the lower of the tumor differentiation and the larger of the tumor diameter. Multivariate analysis revealed lesion diameter (P=0.005), differentiation degree (P=0.007) and invasion depth (P=0.001) were independent risk factors of lymphatic metastasis in esophageal cancer that invaded less than adventitia. Conclusion Depth of tumor invasion, diameter of tumor and tumor differentiation are risk factors of lymph node metastasis of esophageal carcinoma that invades less than adventitia.