CAJ | 학술논문

目的：观察重组人脑利钠肽(rhBNP)对慢性心力衰竭大鼠心室重构及心功能的影响。方法使用阿霉素诱导慢性心力衰竭大鼠模型,用不同剂量 rhBNP 治疗,4周后检测相关指标。结果经 rhBNP 治疗的心力衰竭大鼠中,中、高剂量 rhBNP组左心室质量、左心室质量指数均缩小,左心室长短轴比值增大,但两组比较差异无统计学意义(P >0.05)。经 rhBNP 治疗的心力衰竭大鼠较心力衰竭对照组心功能指标普遍好转,其中以高剂量 rhBNP 组的收缩压、舒张压、左心室收缩压、左心室内压最大上升和下降速度明显升高,左心室舒张末压明显下降(P <0.05)。rhBNP 治疗后的大鼠血清、心肌肿瘤坏死因子α(TNF-α)/IL-10水平普遍出现下降/升高(P <0.05)。结论长期使用 rhBNP 对慢性心力衰竭大鼠心室重构及心功能具有保护作用,其机制可能与 rhBNP 对炎症细胞因子网络的正向调控作用相关。
목적：관찰중조인뇌리납태(rhBNP)대만성심력쇠갈대서심실중구급심공능적영향。방법사용아매소유도만성심력쇠갈대서모형,용불동제량 rhBNP 치료,4주후검측상관지표。결과경 rhBNP 치료적심력쇠갈대서중,중、고제량 rhBNP조좌심실질량、좌심실질량지수균축소,좌심실장단축비치증대,단량조비교차이무통계학의의(P >0.05)。경 rhBNP 치료적심력쇠갈대서교심력쇠갈대조조심공능지표보편호전,기중이고제량 rhBNP 조적수축압、서장압、좌심실수축압、좌심실내압최대상승화하강속도명현승고,좌심실서장말압명현하강(P <0.05)。rhBNP 치료후적대서혈청、심기종류배사인자α(TNF-α)/IL-10수평보편출현하강/승고(P <0.05)。결론장기사용 rhBNP 대만성심력쇠갈대서심실중구급심공능구유보호작용,기궤제가능여 rhBNP 대염증세포인자망락적정향조공작용상관。
Objective To explore the influence of recombinant human brain natriuretic peptide(rhBNP)on the ventricular re-modeling and cardiac function of chronic heart failure rats.Methods Doxorubicin was injected for 2 weeks to obtain the chronic heart failure rats.Then different doses of rhBNP were injected for 4 weeks and objective indexes were recorded.Results The inde-xes were generally improved in the rats with rhBNP injection.The left ventricular absolute weight and left ventricular mass index obviously decreased in both middle and high dose group,but none difference was found between the two groups(P >0.05).The in-dexes of cardiac function of the high dose rhBNP group were improved most obviously,with the systolic pressure,diastolic pres-sure,left ventricular systolic pressure increasing and left ventricular end-diastolic pressure decreasing.right ventricular and diastolic stage decreased significenfly(P <0.05).The serum and myocardial levels of TNF-α/IL-10 generally decreased/increased in the rats after rhBNP treatment(P <0.05).Conclusion Long-term rhBNP treatment is likely to protect the ventricular remodeling and car-diac function and of chronic heart failure,which maybe relative to the positive regulation on inflammatory cytokine network of rhB-NP.