目的 探索失眠障碍不同亚型患者记忆能力和客观睡眠参数之间的差异及其相关性.方法 收集2012年8月至2014年2月在安徽医科大学第一附属医院记忆睡眠障碍门诊就诊的失眠障碍患者89例,其中入睡困难11例,早醒20例,维持困难20例,混合性(至少有2种以上睡眠主诉)38例,用九盒迷宫测试记忆(物体、空间、工作及参考)、多导睡眠图评估患者的睡眠情况.结果 4种类型患者的空间(H=15.404,P=0.002)和工作(H=10.126,P=0.018)记忆错误数差异有统计学意义,即早醒组[6.00(5.00,8.00)、5.00(4.00,6.00)]和混合组[5.00(3.75,7.25)、5.00(2.75,7.00)]的空间记忆和工作记忆均比维持困难组差[2.50(2.00,4.00)、2.00(1.00,4.00);t空间=3.938、3.428,t工作=2.803、2.840;均P＜0.05].4种类型患者之间的睡眠效率(H=7.929,P=0.048)、快速眼动期(REM)睡眠时间(F =2.840,P=0.043)和REM睡眠占总睡眠时间百分比(REM％;H=7.913,P=0.048)差异也存在统计学意义,即混合组[69.7％(50.5％,78.7％)]的睡眠效率比早醒组[81.0％(64.8％,86.4％)]和维持困难组[80.2％(62.6％,88.9％)]低(t=2.242、2.352,均P＜0.05),早醒组[61.6±27.1、16.9％(13.1％,21.9％)]和混合组[56.9±31.4、16.9％ (11.5％,21.2％)]的REM时间(min)和REM％均比维持困难组低[80.9 ±32.7、22.3％(18.5％,25.5％);qREM时间=3.791、5.397,tREM％ =2.513、2.612,均P＜0.05].工作和空间记忆错误数与REM时间(r=-0.387、-0.348,均P＜0.05)和REM％(r=-0.350、-0.354,均P＜0.05)呈负相关.结论 失眠障碍各亚型患者之间的空间和工作记忆能力不同,客观睡眠参数也存在细微差异,且记忆变差可能与REM睡眠减少有关.
目的 探索失眠障礙不同亞型患者記憶能力和客觀睡眠參數之間的差異及其相關性.方法 收集2012年8月至2014年2月在安徽醫科大學第一附屬醫院記憶睡眠障礙門診就診的失眠障礙患者89例,其中入睡睏難11例,早醒20例,維持睏難20例,混閤性(至少有2種以上睡眠主訴)38例,用九盒迷宮測試記憶(物體、空間、工作及參攷)、多導睡眠圖評估患者的睡眠情況.結果 4種類型患者的空間(H=15.404,P=0.002)和工作(H=10.126,P=0.018)記憶錯誤數差異有統計學意義,即早醒組[6.00(5.00,8.00)、5.00(4.00,6.00)]和混閤組[5.00(3.75,7.25)、5.00(2.75,7.00)]的空間記憶和工作記憶均比維持睏難組差[2.50(2.00,4.00)、2.00(1.00,4.00);t空間=3.938、3.428,t工作=2.803、2.840;均P＜0.05].4種類型患者之間的睡眠效率(H=7.929,P=0.048)、快速眼動期(REM)睡眠時間(F =2.840,P=0.043)和REM睡眠佔總睡眠時間百分比(REM％;H=7.913,P=0.048)差異也存在統計學意義,即混閤組[69.7％(50.5％,78.7％)]的睡眠效率比早醒組[81.0％(64.8％,86.4％)]和維持睏難組[80.2％(62.6％,88.9％)]低(t=2.242、2.352,均P＜0.05),早醒組[61.6±27.1、16.9％(13.1％,21.9％)]和混閤組[56.9±31.4、16.9％ (11.5％,21.2％)]的REM時間(min)和REM％均比維持睏難組低[80.9 ±32.7、22.3％(18.5％,25.5％);qREM時間=3.791、5.397,tREM％ =2.513、2.612,均P＜0.05].工作和空間記憶錯誤數與REM時間(r=-0.387、-0.348,均P＜0.05)和REM％(r=-0.350、-0.354,均P＜0.05)呈負相關.結論 失眠障礙各亞型患者之間的空間和工作記憶能力不同,客觀睡眠參數也存在細微差異,且記憶變差可能與REM睡眠減少有關.
목적 탐색실면장애불동아형환자기억능력화객관수면삼수지간적차이급기상관성.방법 수집2012년8월지2014년2월재안휘의과대학제일부속의원기억수면장애문진취진적실면장애환자89례,기중입수곤난11례,조성20례,유지곤난20례,혼합성(지소유2충이상수면주소)38례,용구합미궁측시기억(물체、공간、공작급삼고)、다도수면도평고환자적수면정황.결과 4충류형환자적공간(H=15.404,P=0.002)화공작(H=10.126,P=0.018)기억착오수차이유통계학의의,즉조성조[6.00(5.00,8.00)、5.00(4.00,6.00)]화혼합조[5.00(3.75,7.25)、5.00(2.75,7.00)]적공간기억화공작기억균비유지곤난조차[2.50(2.00,4.00)、2.00(1.00,4.00);t공간=3.938、3.428,t공작=2.803、2.840;균P＜0.05].4충류형환자지간적수면효솔(H=7.929,P=0.048)、쾌속안동기(REM)수면시간(F =2.840,P=0.043)화REM수면점총수면시간백분비(REM％;H=7.913,P=0.048)차이야존재통계학의의,즉혼합조[69.7％(50.5％,78.7％)]적수면효솔비조성조[81.0％(64.8％,86.4％)]화유지곤난조[80.2％(62.6％,88.9％)]저(t=2.242、2.352,균P＜0.05),조성조[61.6±27.1、16.9％(13.1％,21.9％)]화혼합조[56.9±31.4、16.9％ (11.5％,21.2％)]적REM시간(min)화REM％균비유지곤난조저[80.9 ±32.7、22.3％(18.5％,25.5％);qREM시간=3.791、5.397,tREM％ =2.513、2.612,균P＜0.05].공작화공간기억착오수여REM시간(r=-0.387、-0.348,균P＜0.05)화REM％(r=-0.350、-0.354,균P＜0.05)정부상관.결론 실면장애각아형환자지간적공간화공작기억능력불동,객관수면삼수야존재세미차이,차기억변차가능여REM수면감소유관.
Objective To explore the differences of memory functions and objective sleep parameters and their correlations in patients with insomnia disorder in different subtypes.Methods Eightynine patients with insomnia disorder,including 11 patients with difficulty initiating sleep(DIS),20 patients with early morning awakening(EMA),20 patients with difficulty maintaining sleep (DMS) and 38 patients with mixed sleep symptoms(MS) were enrolled between August 2012 and February 2014 in the Memory and Sleep Disorders Clinic of the First Affiliated Hospital of Anhui Medical University.Memory functions,including objective memory,spatial memory,working memory and reference memory were detected with nine boxes maze,and objective sleep profiles were assessed using polysomnography.Results The error numbers of spatial(H =15.404,P =0.002) and working (H =10.126,P =0.018) memories were significantly different among the 4 subtypes of patients,with more errors of spatial and working memory in the EMA (6.00 (5.00,8.00),5.00 (4.00,6.00)) and MS (5.00 (3.75,7.25),5.00 (2.75,7.00)) groups compared with the DMS (2.50 (2.00,4.00),2.00 (1.00,4.00)) group (tspstial =3.938,3.428;t =2.803,2.840;all P ＜ 0.05).Sleep efficiency(H =7.929,P =0.048),REM sleep time(F =2.840,P =0.043) and the percentage of REM sleep time on total sleep time (REM％;H =7.913,P =0.048) were also significantly different among the 4 subtypes of patients,with lower sleep efficiency in the MS(69.7％ (50.5％,78.7％)) group compared with the EMA (81.0％ (64.8％,86.4％)) and DMS (80.2％ (62.6％,88.9％)) groups (t =2.242,2.352;all P ＜ 0.05),less REM sleep time (min) and REM％ in the EMA(61.6 ±27.1,16.9％ (13.1％,21.9％)) and MS(56.9 ±31.4,16.9％ (11.5％,21.2％)) groups compared with the DMS (80.9 ± 32.7,22.3％ (18.5％,25.5％)) group (qREM time =3.791,5.397;tREM％ =2.513,2.612;all P ＜0.05).The error numbers of working memory and spatial memory negatively correlated with the REM sleep time (r =-0.387,-0.348;all P ＜ 0.05) and REM％ (r =-0.350,-0.354;all P ＜ 0.05).Conclusions There are discrepancies in the spatial and working memories and subtle differences in the objective sleep parameters among the patients with different subtypes of insomnia disorder.The worse memories in insomnia disorder patients might be associated with the decreased REM sleep.
