基层医学论坛
基層醫學論罈
기층의학론단
The Medical Forum
2015年
29期
4033-4034
,共2页
慢性粒细胞白血病%骨髓%染色体核型%动态变化
慢性粒細胞白血病%骨髓%染色體覈型%動態變化
만성립세포백혈병%골수%염색체핵형%동태변화
Chronic myelogenous Leukemia%The bone marrow%Karyotype%Dynamic change
目的 对慢性粒细胞白血病患者骨髓细胞染色体核型的变化进行调查和分析. 方法 采用R显带技术对100例慢性粒细胞白血病患者进行骨髓细胞染色体核型分析, 对其病程进展中染色体核型变化进行动态观察. 结果 100例患者中,94例患者Ph染色体呈阳性(Ph+),所占比例为94.0%,6例患者Ph染色体呈阴性(Ph-),所占比例为6.0%;94例Ph+患者中有11例患者出现额外染色体,所占比例为11.7%,其中慢性期患者额外染色体检出率为7.0%, 加速期患者额外染色体检出率为33.3%, 急变期患者额外染色体检出率为80.0%,加速期和急变期额外染色体的检出率明显高于慢性期. 结论 慢性粒细胞白血病患者病程的进展与额外染色体的异常改变具有非常密切的联系, 分析其染色体核型的变化能够为慢性粒细胞白血病的临床诊断和预后判断提供可靠的依据,并为临床治疗提供指导.
目的 對慢性粒細胞白血病患者骨髓細胞染色體覈型的變化進行調查和分析. 方法 採用R顯帶技術對100例慢性粒細胞白血病患者進行骨髓細胞染色體覈型分析, 對其病程進展中染色體覈型變化進行動態觀察. 結果 100例患者中,94例患者Ph染色體呈暘性(Ph+),所佔比例為94.0%,6例患者Ph染色體呈陰性(Ph-),所佔比例為6.0%;94例Ph+患者中有11例患者齣現額外染色體,所佔比例為11.7%,其中慢性期患者額外染色體檢齣率為7.0%, 加速期患者額外染色體檢齣率為33.3%, 急變期患者額外染色體檢齣率為80.0%,加速期和急變期額外染色體的檢齣率明顯高于慢性期. 結論 慢性粒細胞白血病患者病程的進展與額外染色體的異常改變具有非常密切的聯繫, 分析其染色體覈型的變化能夠為慢性粒細胞白血病的臨床診斷和預後判斷提供可靠的依據,併為臨床治療提供指導.
목적 대만성립세포백혈병환자골수세포염색체핵형적변화진행조사화분석. 방법 채용R현대기술대100례만성립세포백혈병환자진행골수세포염색체핵형분석, 대기병정진전중염색체핵형변화진행동태관찰. 결과 100례환자중,94례환자Ph염색체정양성(Ph+),소점비례위94.0%,6례환자Ph염색체정음성(Ph-),소점비례위6.0%;94례Ph+환자중유11례환자출현액외염색체,소점비례위11.7%,기중만성기환자액외염색체검출솔위7.0%, 가속기환자액외염색체검출솔위33.3%, 급변기환자액외염색체검출솔위80.0%,가속기화급변기액외염색체적검출솔명현고우만성기. 결론 만성립세포백혈병환자병정적진전여액외염색체적이상개변구유비상밀절적련계, 분석기염색체핵형적변화능구위만성립세포백혈병적림상진단화예후판단제공가고적의거,병위림상치료제공지도.
Objective In patients with chronic myelogenous leukemia investigation and analysis on the changes of bone marrow cell chromosome karyotype.Methods R banding technique in 100 cases of chronic myelogenous leukemia patients with bone marrow cell chromosome karyotype analysis,the progression of chromosome karyotype changes dynamically observed.Results Of 100 cases,94 cases of patients with Ph chromosome positive(Ph +),the proportion is 94.0%,6 cases with a negative Philadelphia chromosome(Ph-),the proportion is 6.0%;94 cases of patients with Ph + 11 cases patients with extra chromosomes,the proportion is 11.7%,which chronic-phase extra chromosome detection rate was 7.0%,the acceleration period in patients with extra chromosome detection rate was 33.3%,the snap period in patients with extra chromosome detection rate of 80.0%,stage accelerated and snap the extra chromosome detection rate is significantly higher than chronic phase.Conclusions The progress of the course of the disease and patients with chronic myelogenous leukemia extra chromosome anomaly change has very close connection, analysis the changes of chromosome karyotype for chronic myelogenous leukemia a reliable basis for the clinical diagnosis and prognosis of judgment,and provide guidance for clinical treatment.
