CAJ | 학술논문

目的：探讨miR-146 a/133 b在新疆维、汉民族宫颈组织中的差异性表达及其临床意义。方法采用RT-qPCR法检测 miR-146a/133b 在石蜡包埋的宫颈炎、宫颈上皮内瘤变(CIN)和宫颈癌组织中的相对表达量,分析其在宫颈癌发生、发展中的临床意义。结果与宫颈炎组织比,CIN 和宫颈癌组织 miR-146a/133b 的表达水平显著升高(P <0.05),且随宫颈病变的加重,两者的表达水平逐渐升高,宫颈癌组织中维、汉民族 miR-146a 存在差异性表达(P <0.05)。结婚年龄小于20岁、肿瘤直径大于或等于4 cm、有 HPV 感染的宫颈癌组织中 miR-146a/133b 呈高表达(P <0.05)。结论miR-146a/133b 参与宫颈癌的发生、发展,可能成为宫颈癌病情预测及评估新的分子标志物。
목적：탐토miR-146 a/133 b재신강유、한민족궁경조직중적차이성표체급기림상의의。방법채용RT-qPCR법검측 miR-146a/133b 재석사포매적궁경염、궁경상피내류변(CIN)화궁경암조직중적상대표체량,분석기재궁경암발생、발전중적림상의의。결과여궁경염조직비,CIN 화궁경암조직 miR-146a/133b 적표체수평현저승고(P <0.05),차수궁경병변적가중,량자적표체수평축점승고,궁경암조직중유、한민족 miR-146a 존재차이성표체(P <0.05)。결혼년령소우20세、종류직경대우혹등우4 cm、유 HPV 감염적궁경암조직중 miR-146a/133b 정고표체(P <0.05)。결론miR-146a/133b 삼여궁경암적발생、발전,가능성위궁경암병정예측급평고신적분자표지물。
Objective To explore the different expression and clinical significance of miR-146a/133b in cervical tissue in uy-ghur and Han women in Xinjiang.Methods The relative expression of miR-146a/133b in paraffin embedding tissues of cervicitis, CIN and cervical cancer was detected by the RT-qPCR.And analyzed the clinical significance in the development of cervical cancer. Results Compared with cervicitis,the expression of miR-146a/133b increased significantly in CIN and cervical cancer(P <0.05). With the cervical lesion was aggravating,the expression level increased.In cervical cancer tissue,the expression of miR-146a were different between Uyghur and Han women(P <0.05).Marriage age<20 years old,tumor diameter≥4 cm,with HPV infection in cervical cancer tissue,miR-146a/133b had high expression (P <0.05).Conclusion MiR-146a/133b are involved in incidence and development of cervical cancer,they may become new prognostic and evaluating molecular markers in cervical cancer.