CAJ | 학술논문

目的探讨氨甲环酸在单侧全髋关节置换术中局部应用的安全性和有效性.方法 82例单侧股骨颈骨折需行全髋关节置换术的患者被随机分成2组. A组41例,准备缝合切口前予以1. 0 g氨甲环酸10 mL溶液均匀注入关节腔内,术后2 h后开始开放引流管;B组41例,不使用氨甲环酸,仅予以10 mL盐水注射关节腔内.分别计算各组的总失血量、隐性失血量、术后血红蛋白、术后红细胞压积、输血量与输血患者下肢出现深静脉血栓临床症状的例数,术前及术后4h检查血凝常规,并对上述数据进行相应分析.结果 A组与B组总失血量、隐性失血量、输血量、输血人数比较差异具有统计学意义(P<0. 05),A组均低于B组;血凝常规比较差异无统计学意义(P>0. 05),两组均未见深静脉血栓形成.结论氨甲环酸术区局部应用可明显减少行单侧全髋关节置换术的失血量,是一种安全和有效的方法.
목적 탐토안갑배산재단측전관관절치환술중국부응용적안전성화유효성.방법 82례단측고골경골절수행전관관절치환술적환자피수궤분성2조. A조41례,준비봉합절구전여이1. 0 g안갑배산10 mL용액균균주입관절강내,술후2 h후개시개방인류관;B조41례,불사용안갑배산,부여이10 mL염수주사관절강내.분별계산각조적총실혈량、은성실혈량、술후혈홍단백、술후홍세포압적、수혈량여수혈환자하지출현심정맥혈전림상증상적례수,술전급술후4h검사혈응상규,병대상술수거진행상응분석.결과 A조여B조총실혈량、은성실혈량、수혈량、수혈인수비교차이구유통계학의의(P<0. 05),A조균저우B조;혈응상규비교차이무통계학의의(P>0. 05),량조균미견심정맥혈전형성.결론 안갑배산술구국부응용가명현감소행단측전관관절치환술적실혈량,시일충안전화유효적방법.
Objective To explore the safety and efficiency of topical application of tranexamic acid in unilateral total hip replacement. Method A total of 82 patients who received primary unilateral total hip arthroplasty due to femoral neck fracture were randomly divided into two groups. The patients in the experimental group( group A, n=41 ) were injected 1 . 0 g tranexamic acid within 10 mL normal saline into their articular cavity before suturing the incisions. The control group(group B,n=41) were only injected 10 mL normal saline. The drainage tubes of the patients in the two groups were opened 2 hours later. Then,postoperative blood loss,hidden blood loss,the number of hemoglobin and hematocrit,the number of patients accepted blood transfusion and the blood volume were detected and compared. Clinical symptoms such as pulmonary embolism( PE) and lower extremity deep vein thrombosis(DVT) were also observed. Hemagglutination inspection was operated at the 4th hour before and after the surgery. All above data were recorded and analyzed. Results The amounts of blood loss,hidden blood loss, the number of blood transfusion and blood transfusion volume were much lower,while the values of postoperative hemoglobin and hematocrit were significantly higher in the experimental group compared with those in the control group ( P<0 . 05 ) . There was no significant difference in the results of hemagglutination inspection between the two groups(P>0. 05). And no deep venous thrombosis was observed through doppler ultrasound examination. Conclusion The topical application of tranexamic acid in the aged receiving THA could significantly decrease the amount of blood loss and blood transfusion,which is an efficient and safe way to reduce blood loss.