CAJ | 학술논문

目的应用聚类分析及主成分分析探讨2型糖尿病(type 2 diabetes mellitus, T2DM)中医临床证候的分布规律及各证候的主次症,从而为临床辨证提供客观依据. 方法选取我院中医科、内分泌科T2DM患者233例,收集其四诊信息,对四诊信息频数≥10%的54个症状做变量进行聚类分析,归纳出T2DM的中医证候类型. 对各证候的症状、体征、舌脉等进行主成分分析,从而得到各症状对该证候的贡献度,以此判定各证候的主症与次症. 结果 233例T2DM患者四诊信息通过聚类分析后最终聚为5类,分别为脾肾气虚证、肝肾阴虚证、阴虚热盛证、气阴两虚夹痰湿证、阳虚血瘀证. 并在此基础上通过主成分分析初步明确了各证型的主次证. 结论 T2DM可分为5个证候类型,其中以脾肾气虚证居多. 采用聚类分析、主成分分析等统计学方法对T2DM进行证候学研究具有一定的临床意义.
목적 응용취류분석급주성분분석탐토2형당뇨병(type 2 diabetes mellitus, T2DM)중의림상증후적분포규률급각증후적주차증,종이위림상변증제공객관의거. 방법 선취아원중의과、내분비과T2DM환자233례,수집기사진신식,대사진신식빈수≥10%적54개증상주변량진행취류분석,귀납출T2DM적중의증후류형. 대각증후적증상、체정、설맥등진행주성분분석,종이득도각증상대해증후적공헌도,이차판정각증후적주증여차증. 결과 233례T2DM환자사진신식통과취류분석후최종취위5류,분별위비신기허증、간신음허증、음허열성증、기음량허협담습증、양허혈어증. 병재차기출상통과주성분분석초보명학료각증형적주차증. 결론 T2DM가분위5개증후류형,기중이비신기허증거다. 채용취류분석、주성분분석등통계학방법대T2DM진행증후학연구구유일정적림상의의.
Objective To investigate the distribution regularities of type 2 diabetes mellitus (T2DM) patients in traditional Chinese medicine ( TCM) of clinical syndrome types and the main and secondary symptoms of each syndrome type using cluster analysis and principal component analysis so as to provide objective basis for clinical syndrome differen-tiation. Methods Informations by four diagnostic methods of 233 T2DM patients were collected, and 54 symptoms (fre-quency ≥10%) were used as variables for cluster analysis to generalize TCM syndromes of T2DM. Principal component analysis was performed for the symptoms, signs, tongue and pulse conditions of each syndrome type, and then the contri-bution of each symptom to its syndrome was obtained in order to find out the main and secondary symptoms of each syn-drome type. Results Informations of four diagnostic methods of the T2DM 233 patients were clustered into five types by cluster analysis, which included spleen-kidney Qi deficiency syndrome, syndrome of Yin deficiency of liver and kidney, deficiency of Yin and excessive heat syndrome, deficiency of both Qi and Yin with phlegm retention syndrome, and Yang deficiency and blood stasis syndrome, and then the primary and secondary symptoms of each syndrome type were prelimi-narily clarified by principal component analysis. Conclusion T2DM can be divided into five syndrome types, among which spleen-kidney deficiency syndrome is the most. Statistical methods such as cluster and principal component analy-ses for TCM syndrome study have some clinical significance.