CAJ | 학술논문

目的探讨银屑病( psoriasis, PS)合并代谢综合征( metabolic syndrome, MS)患者超敏-C反应蛋白( hs-CRP)、白细胞介素-6(IL-6)水平以及理化指标变化特点,为进一步研究PS合并MS发病机制奠定基础. 方法对74例PS合并MS患者(观察组) hs-CRP、IL-6以及理化指标进行检测,同时与单纯银屑病患者( PS组,40例)、正常对照组(体检健康者,70例)进行比较. 结果观察组IL-6、hs-CRP 水平均高于PS组,差异有统计学意义(P<0. 01);观察组白细胞( WBC)、中性粒细胞( NEU)、淋巴细胞( LYM)、嗜酸粒细胞( EOS)、红细胞平均血红蛋白( MCH)、血小板压积(PCT)均高于正常对照组(P<0. 05),红细胞平均体积(MCV)比较差异无统计学意义(P>0. 05);PS组EOS、MCV、MCH、PCT均高于正常对照组(P<0. 05);观察组WBC、NEU及LYM均高于PS组(P<0. 05),MCV、MCH、PCT与PS组比较均无统计学意义(P>0. 05). 结论 PS合并MS患者炎症状态较单纯PS患者更加明显,MS会加重PS患者的炎症状态,且PS患者血液黏稠度高.
목적 탐토은설병( psoriasis, PS)합병대사종합정( metabolic syndrome, MS)환자초민-C반응단백( hs-CRP)、백세포개소-6(IL-6)수평이급이화지표변화특점,위진일보연구PS합병MS발병궤제전정기출. 방법 대74례PS합병MS환자(관찰조) hs-CRP、IL-6이급이화지표진행검측,동시여단순은설병환자( PS조,40례)、정상대조조(체검건강자,70례)진행비교. 결과 관찰조IL-6、hs-CRP 수평균고우PS조,차이유통계학의의(P<0. 01);관찰조백세포( WBC)、중성립세포( NEU)、림파세포( LYM)、기산립세포( EOS)、홍세포평균혈홍단백( MCH)、혈소판압적(PCT)균고우정상대조조(P<0. 05),홍세포평균체적(MCV)비교차이무통계학의의(P>0. 05);PS조EOS、MCV、MCH、PCT균고우정상대조조(P<0. 05);관찰조WBC、NEU급LYM균고우PS조(P<0. 05),MCV、MCH、PCT여PS조비교균무통계학의의(P>0. 05). 결론 PS합병MS환자염증상태교단순PS환자경가명현,MS회가중PS환자적염증상태,차PS환자혈액점주도고.
Objective To explore the characteristics of hs-CRP and interleukin-6 (IL-6) levels and changes of physical and chemical indexes in blood of psoriasis ( PS) patients with metabolic syndrome ( MS) so as to provide the foundation for further studying the pathogenesy of PS complicated with MS. Methods The hs-CRP and IL-6 levels and physical and chemical indexes of 74 PS patients with MS ( observation group) were detected, meanwhile the results were compared with those in psoriasis patients (PS group, n=40) and normal controls (NC group, n=70). Results In ob-servation group, the IL-6 and hs-CRP levels were higher than those in PS group, and the differences were statistically sig-nificant (P<0. 01);the values of leukocyte (WBC), neutrophil (NEU), lymphocytes (LYM), eosinophils (EOS), mean corpuscular hemoglobin ( MCH ) and platelet hematocrit ( PCT ) were higher than those in the NC group ( P <0. 05), while the difference in mean corpuscular volume (MCV) was not statistically significant (P>0. 05). The values of EOS, MCV, MCH and PCT in PS group were higher than those in the NC group (P<0. 05). The values of WBC, NEU and LYM in observation group were higher than those in the PS group (P<0. 05), while the differences in values of MCV, MCH and PCT were no statistically significant compared with those in PS group (P>0. 05). Conclusion The inflammation status of PS patients with MS can be found more obvious than that in the PS patients, and MS may increase inflammation in PS patients with a high level of blood viscosity.