临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
Chinese Journal of Clinical Rational Drug Use
2015年
28期
8-10
,共3页
张宇峰%付培亭%刘秀宝%马利燕
張宇峰%付培亭%劉秀寶%馬利燕
장우봉%부배정%류수보%마리연
当归补血汤%重组人粒细胞刺激因子%乳腺癌%化学治疗
噹歸補血湯%重組人粒細胞刺激因子%乳腺癌%化學治療
당귀보혈탕%중조인립세포자격인자%유선암%화학치료
Angelica blood tonic soup%Recombinant human granulocyte colony-stimulating factor%Breast cancer%Chemotherapy
目的：探讨当归补血汤联合重组人粒细胞刺激因子防治乳腺癌化疗后骨髓抑制的效果。方法将60例乳腺癌化疗患者随机分为治疗组与对照组各30例。治疗组给予当归补血汤及重组人粒细胞刺激因子治疗，对照组仅给予重组人粒细胞刺激因子治疗。对比2组骨髓抑制情况和化疗后感染情况。结果2组患者化疗前白细胞计数比较差异无统计学意义（P＞0．05）；而治疗组化疗第7、14、21天白细胞计数高于对照组（P＜0．05）。对照组化疗前后白细胞水平变化差异无统计学意义（P＞0．05）。治疗组化疗后白细胞、粒细胞、血红蛋白、血小板Ⅲ～Ⅳ度抑制情况明显轻于对照组（P＜0．05）。在整个治疗周期中，治疗组感染发生率为3．3％（1／30）低于对照组的26．7％（8／30）（P＜0．05）。结论当归补血汤联合皮下注射重组人粒细胞刺激因子可防治乳腺癌化疗后骨髓抑制，值得临床推广应用。
目的：探討噹歸補血湯聯閤重組人粒細胞刺激因子防治乳腺癌化療後骨髓抑製的效果。方法將60例乳腺癌化療患者隨機分為治療組與對照組各30例。治療組給予噹歸補血湯及重組人粒細胞刺激因子治療，對照組僅給予重組人粒細胞刺激因子治療。對比2組骨髓抑製情況和化療後感染情況。結果2組患者化療前白細胞計數比較差異無統計學意義（P＞0．05）；而治療組化療第7、14、21天白細胞計數高于對照組（P＜0．05）。對照組化療前後白細胞水平變化差異無統計學意義（P＞0．05）。治療組化療後白細胞、粒細胞、血紅蛋白、血小闆Ⅲ～Ⅳ度抑製情況明顯輕于對照組（P＜0．05）。在整箇治療週期中，治療組感染髮生率為3．3％（1／30）低于對照組的26．7％（8／30）（P＜0．05）。結論噹歸補血湯聯閤皮下註射重組人粒細胞刺激因子可防治乳腺癌化療後骨髓抑製，值得臨床推廣應用。
목적：탐토당귀보혈탕연합중조인립세포자격인자방치유선암화료후골수억제적효과。방법장60례유선암화료환자수궤분위치료조여대조조각30례。치료조급여당귀보혈탕급중조인립세포자격인자치료，대조조부급여중조인립세포자격인자치료。대비2조골수억제정황화화료후감염정황。결과2조환자화료전백세포계수비교차이무통계학의의（P＞0．05）；이치료조화료제7、14、21천백세포계수고우대조조（P＜0．05）。대조조화료전후백세포수평변화차이무통계학의의（P＞0．05）。치료조화료후백세포、립세포、혈홍단백、혈소판Ⅲ～Ⅳ도억제정황명현경우대조조（P＜0．05）。재정개치료주기중，치료조감염발생솔위3．3％（1／30）저우대조조적26．7％（8／30）（P＜0．05）。결론당귀보혈탕연합피하주사중조인립세포자격인자가방치유선암화료후골수억제，치득림상추엄응용。
Objective To observe the effect of angelica blood tonic soup combined with recombinant human granulo -cytecolony-stimulating factor in bone marrow suppression after chemotherapy of breastcancer.Methods 60casesofpatients with breast cancer treated by chemotherapy randomly divided into treatment group and control group ,each of 30 cases.The con-trol group treated by recombinant human granulocyte stimulating factor .The treatment group ,on the basis of control group ,trea-ted by angelica blood tonic soup .After treatment,compared the bone marrow suppression and the incidence of infection after chemotherapy.Results The white blood cell count before chemotherapy has no statistically significant (P>0.05).The white blood cell count of treatment group in 7th,14th,21th after chemotherapy were higher than that of control group ,the difference was statistically significant(P<0.05).The white blood cell count before and after chemotherapy was no statistically significant (P>0.05).The inhibition of white blood cells ,neutropenia,hemoglobin and platelet of treament group after chemotherapy were Lighter than that of control group (P<0.05).The infection incidence of treatment (3.3%,1/30)was lower than that of control group(26.7%,8/30)(P<0.05).Conclusion Angelica blood tonic soup combined with recombinant human granulo-cyte colony-stimulating factor in bone marrow suppression after chemotherapy of breast cancer has an good effect , worthy of clinical application .
