CAJ | 학술논문

目的探讨河北汉族人群对氧磷酶2（ PON2） C311S基因多态性的分布情况。方法应用聚合酶链式反应-限制性酶切片段长度多态性（PCR-RFLP）方法对209例河北汉族正常人进行PON2 C311S基因多态性分析。结果河北汉族人群PON2 C311S基因多态性符合Hardy-Weinberg 遗传平衡定律，具有代表性。 PON2 C311S基因CC基因型、CS基因型、SS基因型分别占3．3％、31．1％、65．6％。结论河北汉族人群PON2 C311S基因存在多态性，此人群PON2 C311S基因型分布与海南地区黎族、湖南地区汉族、日本人群一致，而与海南地区汉族、北京地区人群、印度人群、伊朗人群有明显差别。
목적탐토하북한족인군대양린매2（ PON2） C311S기인다태성적분포정황。방법응용취합매련식반응-한제성매절편단장도다태성（PCR-RFLP）방법대209례하북한족정상인진행PON2 C311S기인다태성분석。결과하북한족인군PON2 C311S기인다태성부합Hardy-Weinberg 유전평형정률，구유대표성。 PON2 C311S기인CC기인형、CS기인형、SS기인형분별점3．3％、31．1％、65．6％。결론하북한족인군PON2 C311S기인존재다태성，차인군PON2 C311S기인형분포여해남지구려족、호남지구한족、일본인군일치，이여해남지구한족、북경지구인군、인도인군、이랑인군유명현차별。
Objective To study the paraoxonase 2 ( PON2) C311S genetic polymorphisms among healthy Han population of Hebei province .Methods Using polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) to detect the genotypes of PON 2 C311S in 209 healthy Han population of Hebei province .Rseults The genotype distribution of the healthy Hebei Han population was in good agreement with Hardy -Weinberg equilibrium .The PON2 C311S genotype frequency for types of CC ,CS and SS were 3.3%,31.1%,65.6%. Conclusion The results suggest that there exist polymorphisms in PON 2 C311S among healthy Han population of Hebei province .The PON2 C311S gene polymorphism in Hebei healthy Han population is similar to Hainan Li nationality ,Hunan Han population and Japanese population , but significantly different form Hainan Han nationality , Beijing population ,India's population and Iran's population .