CAJ | 학술논문

目的整体身心调节干预对颅脑损伤认知障碍患者血清脑源性神经营养因子（ BDNF）的影响。方法采用投掷硬币随机分组法将85例认知障碍的颅脑损伤患者分为对照组（42例）和身心调节干预组（43例）。对照组给予针对性的认知康复训练，身心调节干预组在此基础上给予身心调节干预训练。采用执行缺陷综合征的行为评价（ BADS）和洛文斯顿作业疗法认知评定测验（ LOTCA）量表进行执行功能及认知能力评测；酶联免疫吸附试验（ ELISE）检测血清BDNF的浓度。结果治疗前，两组患者的BADS各项指标评分以及LOTCA评分差异无统计学意义（P＞0．05），BDNF浓度变化差异无统计学意义（P＞0．05）；治疗后，身心调节干预组BADS各项指标评分以及LOTCA评分优于对照组， BDNF血清浓度较对照组升高，差异有统计学意义（ P＜0．05）。结论整体身心调节行为干预可改善颅脑损伤患者执行功能障碍，与提高血清脑源性生长因子的浓度有关。
목적정체신심조절간예대로뇌손상인지장애환자혈청뇌원성신경영양인자（ BDNF）적영향。방법채용투척경폐수궤분조법장85례인지장애적로뇌손상환자분위대조조（42례）화신심조절간예조（43례）。대조조급여침대성적인지강복훈련，신심조절간예조재차기출상급여신심조절간예훈련。채용집행결함종합정적행위평개（ BADS）화락문사돈작업요법인지평정측험（ LOTCA）량표진행집행공능급인지능력평측；매련면역흡부시험（ ELISE）검측혈청BDNF적농도。결과치료전，량조환자적BADS각항지표평분이급LOTCA평분차이무통계학의의（P＞0．05），BDNF농도변화차이무통계학의의（P＞0．05）；치료후，신심조절간예조BADS각항지표평분이급LOTCA평분우우대조조， BDNF혈청농도교대조조승고，차이유통계학의의（ P＜0．05）。결론정체신심조절행위간예가개선로뇌손상환자집행공능장애，여제고혈청뇌원성생장인자적농도유관。
Objective To explore the influence of integrative body-mind training on the brain derived neurotrophic factors ( BDNF) in serum of patients with traumatic brain injury .Methods Randomly divided 85 cases into integrative body-mind training group(n=43)and control group(n=42).The control group took targeted cognitive interventions therapy .The treatment group with body-mind training combined coith cognitive training .The cognitive function and executive function were detected by the Behavioral Assessment of Dysexecutive Syndrome ( BADS) and Loewenstein Occupation Therapy Cognitive Assessment ( LOTCA).The level of BAND in serum was detected with enzyme linked immunosorbent assay .Results Before training, there was no significant difference in every BADS , LOTCA index and BAND level (P>0.05), After training, After training, they were much improved.Moreover,they were much more improved in integrativebody-mind group were improved more than in control group ( P<0.05 ) . Conclusion Integrative body-mind training can improve the recovery of executive function and cognitive function with traumatic brain injury , which is related to the brain derived neurotrophic factors .