CAJ | 학술논문

目的观察补肾活血汤联合唑来膦酸治疗乳腺癌骨转移的临床疗效. 方法将乳腺癌骨转移患者46例随机分为观察组及对照组各23例,观察组给予补肾活血汤联合唑来膦酸治疗,对照组单用唑来膦酸治疗, 1个月为1 疗程,共治疗4个疗程. 观察比较治疗后两组患者的骨质修复疗效及疼痛评分(NRS评分)、Karnofsky评分变化. 结果观察组骨质修复总有效率为86.9%,对照组为60.9%,两组差异有统计学意义(P<0.05);观察组NRS评分及Karnofsky评分改善均优于对照组,差异有统计学意义(P<0.05).结论补肾活血汤联合唑来膦酸治疗乳腺癌骨转移在骨质修复及减轻患者疼痛方面优于单用唑来膦酸,同时在提高患者生存质量方面具有一定优势.
목적 관찰보신활혈탕연합서래련산치료유선암골전이적림상료효. 방법 장유선암골전이환자46례수궤분위관찰조급대조조각23례,관찰조급여보신활혈탕연합서래련산치료,대조조단용서래련산치료, 1개월위1 료정,공치료4개료정. 관찰비교치료후량조환자적골질수복료효급동통평분(NRS평분)、Karnofsky평분변화. 결과 관찰조골질수복총유효솔위86.9%,대조조위60.9%,량조차이유통계학의의(P<0.05);관찰조NRS평분급Karnofsky평분개선균우우대조조,차이유통계학의의(P<0.05).결론 보신활혈탕연합서래련산치료유선암골전이재골질수복급감경환자동통방면우우단용서래련산,동시재제고환자생존질량방면구유일정우세.
Objective To investigate the effects of Bushen Huoxue Decoction combined with zoledronic acid on bone metastasis in breast cancer patients. Methods 46 cases of breast cancer patients with bone metastasis were randomly divided into the observation group and control group, 23 cases in each group. The observation group were treated with Bushen Huoxue Decoction combined with zoledronic acid, and the control group were given zoledronic acid only, one month for a course, continuously for 4 cycles. The changes of bone repair efficiency, NRS and Karnofsky score in two groups were compared. Results The bone repair efficiency in the observation group was 86.9%, the control group was 60.87%, the differences between the two groups have statistical significance (P<0.05); The NRS and Karnofsky score in the observation group were better than that of the control group, the differences were statistically significant (P<0.05). Conclusion Bushen Huoxue Decoction combined with zoledronic acid can be used for the treatment of breast cancer with bone metastasis, the effect of bone repair and alleviating the pain of the patients in the observation group was significantly better than the control group, it also has certain advantages in improving the quality of life of patients.