湖南中医药大学学报
湖南中醫藥大學學報
호남중의약대학학보
Journal of Traditional Chinese Medicine University of Hunan
2015年
9期
31-32,69
,共3页
五指毛桃%阿尔茨海默病%记忆功能%过氧化损伤
五指毛桃%阿爾茨海默病%記憶功能%過氧化損傷
오지모도%아이자해묵병%기억공능%과양화손상
radix fici hirtae%Alzheimer's disease%memory function%oxidative damage
目的 探讨五指毛桃对阿尔茨海默病(Alzheimer's disease,AD)小鼠记忆功能及过氧化损伤的影响. 方法 AlCl3灌胃建立AD小鼠模型,受试药物组以五指毛桃进行灌胃,通过水迷宫试验,研究不同剂量[36、18、9 g/(kg·d)]五指毛桃对AD小鼠记忆功能的影响;通过检测其对各组小鼠大脑中丙二醛(MDA)及超氧化物歧化酶(SOD)含量的影响,来探讨五指毛桃的抗氧化作用. 结果 中、高剂量组五指毛桃能显著提高AD小鼠记忆功能(P<0.01);且能有效降低AD小鼠大脑中的MDA含量(P<0.05或P<0.01);有效提高AD小鼠大脑中的SOD含量(P<0.05或P<0.01). 结论 五指毛桃能有效改善AD小鼠的记忆功能,其主要机制可能与其抗氧化作用有关.
目的 探討五指毛桃對阿爾茨海默病(Alzheimer's disease,AD)小鼠記憶功能及過氧化損傷的影響. 方法 AlCl3灌胃建立AD小鼠模型,受試藥物組以五指毛桃進行灌胃,通過水迷宮試驗,研究不同劑量[36、18、9 g/(kg·d)]五指毛桃對AD小鼠記憶功能的影響;通過檢測其對各組小鼠大腦中丙二醛(MDA)及超氧化物歧化酶(SOD)含量的影響,來探討五指毛桃的抗氧化作用. 結果 中、高劑量組五指毛桃能顯著提高AD小鼠記憶功能(P<0.01);且能有效降低AD小鼠大腦中的MDA含量(P<0.05或P<0.01);有效提高AD小鼠大腦中的SOD含量(P<0.05或P<0.01). 結論 五指毛桃能有效改善AD小鼠的記憶功能,其主要機製可能與其抗氧化作用有關.
목적 탐토오지모도대아이자해묵병(Alzheimer's disease,AD)소서기억공능급과양화손상적영향. 방법 AlCl3관위건립AD소서모형,수시약물조이오지모도진행관위,통과수미궁시험,연구불동제량[36、18、9 g/(kg·d)]오지모도대AD소서기억공능적영향;통과검측기대각조소서대뇌중병이철(MDA)급초양화물기화매(SOD)함량적영향,래탐토오지모도적항양화작용. 결과 중、고제량조오지모도능현저제고AD소서기억공능(P<0.01);차능유효강저AD소서대뇌중적MDA함량(P<0.05혹P<0.01);유효제고AD소서대뇌중적SOD함량(P<0.05혹P<0.01). 결론 오지모도능유효개선AD소서적기억공능,기주요궤제가능여기항양화작용유관.
Objective To investigate the effect of radix fici hirtae on the memory function and oxidative damage in Alzheimer's mice. Methods The AD model mice were established by feeding AlCl3 and the test drugs groups were given by gavage radix fici hirtae. The effect of different doses (36 g/kg·d,18 g/kg·d,9 g/kg·d)radix fici hirtae on the memory function of AD mice was investigated by Morris water maze test. In addition, the antioxidant effect was discussed by its impact on MDA and SOD in mice brain. Results The medium and high doses of radix fici hirtae can improve the memory function of AD mice (P<0.01), reduce MDA content in AD mice brain (P<0.05 or P<0.01), and improve the content of SOD in the brain of AD mice (P<0.05 or P<0.01). Conclusion Radix fici hirtae can effectively improve memory function of AD mice and its main mechanism may be related to its antioxidant effect.
