CAJ | 학술논문

目的探讨眩晕定颗粒对家兔气虚血瘀型后循环缺血性眩晕模型前庭神经核区Bax、Bcl-2及脑源性神经生长因子(BDNF)表达的影响. 方法建立气虚血瘀型后循环缺血性眩晕家兔模型,以西比灵为西药对照,眩晕宁为中药对照,免疫组化法测定前庭神经核区Bax、Bcl-2和BDNF表达. 结果造模后模型组家兔脑干前庭神经核Bcl-2 及BDNF表达显著下降,Bax 表达上调,差异有统计学意义(P<0.05);药物干预后,与模型组比较,眩晕定颗粒使家兔脑干前庭神经核 Bcl-2 及BDNF表达上调,并可抑制Bax的表达. 结论眩晕定颗粒治疗家兔实验性眩晕的作用与其促进脑组织Bcl-2、BDNF表达,抑制Bax表达有关.
목적 탐토현훈정과립대가토기허혈어형후순배결혈성현훈모형전정신경핵구Bax、Bcl-2급뇌원성신경생장인자(BDNF)표체적영향. 방법 건립기허혈어형후순배결혈성현훈가토모형,이서비령위서약대조,현훈저위중약대조,면역조화법측정전정신경핵구Bax、Bcl-2화BDNF표체. 결과 조모후모형조가토뇌간전정신경핵Bcl-2 급BDNF표체현저하강,Bax 표체상조,차이유통계학의의(P<0.05);약물간예후,여모형조비교,현훈정과립사가토뇌간전정신경핵 Bcl-2 급BDNF표체상조,병가억제Bax적표체. 결론 현훈정과립치료가토실험성현훈적작용여기촉진뇌조직Bcl-2、BDNF표체,억제Bax표체유관.
Objective To investigate the effect of Xuanyunding Granules on the expression of Bax, Bcl-2 and BDNF in PCIV model rabbits with the syndrome of Qi deficiency and blood stasis (QDBS). Methods The PCIV model rabbits with QDBS were prepared,Sibelium as the control of Western medicine and Xuanyunning as the control of Chinese medicine. The expression of Bax, Bcl-2 and BDNF was tested by immuohistochemisty. Results After the modeling, the contents of Bcl-2 and BDNF were lower obviously, and the expression of Bax was higher, the difference has statistical significance (P<0.05). After the medicine intervention, compared with model group, Xuanyunding Granules could improve the expression of Bcl-2 and BDNF, and reduced the Bax expression. Conclusion Xuanyunding Granules in the treatment of vertigo in rabbits is related with its promoting the expression of Bcl-2 and BDNF, and inhibiting the Bax expression.