中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
Chinese Journal of Behavioral Medicine and Brain Science
2015年
8期
726-729
,共4页
抽动症%多巴胺D3%基因多态性%疗效%阿立哌唑
抽動癥%多巴胺D3%基因多態性%療效%阿立哌唑
추동증%다파알D3%기인다태성%료효%아립고서
Childhood tourette syndrome%Dopamine D3 receptor%Gene polymorphism%Therapeutic efficacy%Aripiprazole
目的 探讨阿立哌唑(aripiprazole)治疗儿童期抽动症疗效与多巴胺D3受体(DRD3)第一外显子Ser9Gly多态性关联性.方法 158例符合ICD-10抽动症的诊断患者作为研究对象,采用阿立哌唑治疗8周,用耶鲁抽动症严重程度量表(Yale global tic severity scale,YGTSS)评定疗效.应用聚合酶链反应-限制性片段长度的多态性技术对抽动症患儿和健康患儿对照(n=187)的基因进行遗传关联分析.结果 ①经过对DRD3基因的Ser9Gly基因型及等位基因频率比较,病例组和对照组之间差异均无统计学意义(P＞0.05).②病例组中有效组与无效组DRD3 Ser9Gly基因型(Ser/Ser:40 vs 17;Ser/Gly:52 vs 28;Gly/Gly:7 vs 14)及等位基因频率(Ser:132 vs 62;Gly:66 vs 56)比较,均差异有统计学意义(P＜0.05).③病例组一过性抽动障碍、慢性抽动和发声与多种运动联合抽动障碍(TS)三种类型的DRD3 Ser9Gly基因型及等位基因频率比较,均差异无统计学意义(P＞0.05).结论 多巴胺D3受体基因多态性与阿立哌唑疗效有关联性,与抽动症分型无关联性.
目的 探討阿立哌唑(aripiprazole)治療兒童期抽動癥療效與多巴胺D3受體(DRD3)第一外顯子Ser9Gly多態性關聯性.方法 158例符閤ICD-10抽動癥的診斷患者作為研究對象,採用阿立哌唑治療8週,用耶魯抽動癥嚴重程度量錶(Yale global tic severity scale,YGTSS)評定療效.應用聚閤酶鏈反應-限製性片段長度的多態性技術對抽動癥患兒和健康患兒對照(n=187)的基因進行遺傳關聯分析.結果 ①經過對DRD3基因的Ser9Gly基因型及等位基因頻率比較,病例組和對照組之間差異均無統計學意義(P＞0.05).②病例組中有效組與無效組DRD3 Ser9Gly基因型(Ser/Ser:40 vs 17;Ser/Gly:52 vs 28;Gly/Gly:7 vs 14)及等位基因頻率(Ser:132 vs 62;Gly:66 vs 56)比較,均差異有統計學意義(P＜0.05).③病例組一過性抽動障礙、慢性抽動和髮聲與多種運動聯閤抽動障礙(TS)三種類型的DRD3 Ser9Gly基因型及等位基因頻率比較,均差異無統計學意義(P＞0.05).結論 多巴胺D3受體基因多態性與阿立哌唑療效有關聯性,與抽動癥分型無關聯性.
목적 탐토아립고서(aripiprazole)치료인동기추동증료효여다파알D3수체(DRD3)제일외현자Ser9Gly다태성관련성.방법 158례부합ICD-10추동증적진단환자작위연구대상,채용아립고서치료8주,용야로추동증엄중정도량표(Yale global tic severity scale,YGTSS)평정료효.응용취합매련반응-한제성편단장도적다태성기술대추동증환인화건강환인대조(n=187)적기인진행유전관련분석.결과 ①경과대DRD3기인적Ser9Gly기인형급등위기인빈솔비교,병례조화대조조지간차이균무통계학의의(P＞0.05).②병례조중유효조여무효조DRD3 Ser9Gly기인형(Ser/Ser:40 vs 17;Ser/Gly:52 vs 28;Gly/Gly:7 vs 14)급등위기인빈솔(Ser:132 vs 62;Gly:66 vs 56)비교,균차이유통계학의의(P＜0.05).③병례조일과성추동장애、만성추동화발성여다충운동연합추동장애(TS)삼충류형적DRD3 Ser9Gly기인형급등위기인빈솔비교,균차이무통계학의의(P＞0.05).결론 다파알D3수체기인다태성여아립고서료효유관련성,여추동증분형무관련성.
Objective To investigate the association of polymorphisms in dopamine D3 receptor (DRD3) gene exon 1 Ser9Gly with childhood tourette syndrome and efficacy of aripiprazole in Chinese Han population.Methods Polymorphisms of Ser9Gly in DRD3 gene was genotyped by using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) in 158 tourette syndrome patients (study group) and 187 healthy controls (control group).Patients in study group were assessed with Yale global tic severity scale(YGTSS) at baseline and at the end of the 8th week of treatment to evaluate the efficacy of aripiprazole.Results (1) There were no significant differences in genotypic frequency and allelic frequency of Ser9Gly in DRD3 gene between study group and control group (P＞0.05).(2) Significant difference was found in frequency of Ser9Gly in DRD3 gene between effective and ineffective groups (genotype:Ser/Ser 40 vs 17;Ser/Gly 52 vs 28;Gly/Gly 7 vs 14;alle:Ser 132 vs 62;Gly 66 vs 56)(P＜0.05).(3) There were no significant differences in distribution of genotypes and alleles of Ser9Gly among three-type of tourette syndrome (P＞0.05).Conclusion The polymorphisms of Ser9Gly in DRD3 gene are associated with the efficacy of aripiprazole.
