中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
Chinese Journal of Behavioral Medicine and Brain Science
2015年
8期
719-721
,共3页
易阳%董选%沈惠娟%陈琳%江凯华%赵方乔%屠文娟%吴婷
易暘%董選%瀋惠娟%陳琳%江凱華%趙方喬%屠文娟%吳婷
역양%동선%침혜연%진림%강개화%조방교%도문연%오정
注意缺陷多动障碍%数学认知%注意认知%事件相关电位%执行功能
註意缺陷多動障礙%數學認知%註意認知%事件相關電位%執行功能
주의결함다동장애%수학인지%주의인지%사건상관전위%집행공능
Attention deficit hyperactivity disorder children%Mathematic cognition%Event-related potentials%Attention%Executive function
目的 采用数学与注意两种事件相关电位(ERP)探讨注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)儿童执行功能(EF)损害的神经机制.方法 对象ADHD组45例,正常对照组45名,年龄8～11岁,两组年龄、性别相匹配.两组儿童均使用数学与注意ERP任务检测,并与正常儿童比较分析.结果 ①计算判断ERP:ADHD儿童错误答案判断N2波幅(μV)低于正常儿童[(-11.86±6.01) μ V vs(-8.38±3.52)μV],差异有统计学意义(P＜0.05);两组儿童正确答案判断比较差异无统计学意义(P＞0.05).②注意ERP:ADHD儿童CPT非靶P3波幅低于正常儿童[(21.92±13.43) μ V vs (30.65±17.10)μV],差异有统计学意义(P＜0.05).结论 ADHD儿童在计算答案判断N2波幅的降低,提示执行功能的工作记忆和决策能力的下降;CPT非靶P3波幅的降低反映执行功能的反应抑制缺陷.数学N2及注意CP3可作为联合评估执行功能障碍的敏感指标.
目的 採用數學與註意兩種事件相關電位(ERP)探討註意缺陷多動障礙(attention deficit hyperactivity disorder,ADHD)兒童執行功能(EF)損害的神經機製.方法 對象ADHD組45例,正常對照組45名,年齡8～11歲,兩組年齡、性彆相匹配.兩組兒童均使用數學與註意ERP任務檢測,併與正常兒童比較分析.結果 ①計算判斷ERP:ADHD兒童錯誤答案判斷N2波幅(μV)低于正常兒童[(-11.86±6.01) μ V vs(-8.38±3.52)μV],差異有統計學意義(P＜0.05);兩組兒童正確答案判斷比較差異無統計學意義(P＞0.05).②註意ERP:ADHD兒童CPT非靶P3波幅低于正常兒童[(21.92±13.43) μ V vs (30.65±17.10)μV],差異有統計學意義(P＜0.05).結論 ADHD兒童在計算答案判斷N2波幅的降低,提示執行功能的工作記憶和決策能力的下降;CPT非靶P3波幅的降低反映執行功能的反應抑製缺陷.數學N2及註意CP3可作為聯閤評估執行功能障礙的敏感指標.
목적 채용수학여주의량충사건상관전위(ERP)탐토주의결함다동장애(attention deficit hyperactivity disorder,ADHD)인동집행공능(EF)손해적신경궤제.방법 대상ADHD조45례,정상대조조45명,년령8～11세,량조년령、성별상필배.량조인동균사용수학여주의ERP임무검측,병여정상인동비교분석.결과 ①계산판단ERP:ADHD인동착오답안판단N2파폭(μV)저우정상인동[(-11.86±6.01) μ V vs(-8.38±3.52)μV],차이유통계학의의(P＜0.05);량조인동정학답안판단비교차이무통계학의의(P＞0.05).②주의ERP:ADHD인동CPT비파P3파폭저우정상인동[(21.92±13.43) μ V vs (30.65±17.10)μV],차이유통계학의의(P＜0.05).결론 ADHD인동재계산답안판단N2파폭적강저,제시집행공능적공작기억화결책능력적하강;CPT비파P3파폭적강저반영집행공능적반응억제결함.수학N2급주의CP3가작위연합평고집행공능장애적민감지표.
Objective To explore the features of mathematics and attention event-related potential for children with ADHD and impaired neural mechanisms of executive function (EF).Methods The two groups children,45 ADHD children and 45 normal children,were eight-to-eleven-year-old and there were no significant differences in the age and sex of two groups children.Both children performed mathematic and continuous performance test (CPT) tasks.Results Fz in Mathematic ERP:The N2 amplitudes (μV) in children with ADHD were significantly lower than those of control group in deciding error ((-11.86±6.01) μV vs (-8.38±3.52) μV),P＜0.05),and there were no significant differences in deciding right between ADHD and normal control group (P＞0.05).CPT:The Nogo P3 amplitudes in children with ADHD were significantly lower than control group((21.92± 13.43)μV vs (30.65± 17.10)μV),P＜0.05).Conclusion The decrease of N2 amplitude while in deciding error indicate EF impairments deficits in working memory and decision-making ability.Nogo P3 amplitude of continuous performance task (CPT) in ADHD children indicate EF impairments deficits iu response inhibition.Both P3 in attention CPT and N2 in mathematics could be used as sensitive index of EF impairments.
