CAJ | 학술논문

目的探讨伴认知功能障碍帕金森病(Parkinson's discase,PD)的脑葡萄糖代谢特征和变化过程,寻求PD认知相关的新型生物学标志物.方法将临床诊断为原发性帕金森病患者50例进行MMSE评分,分为25例认知功能正常组(PD-NC)、25例伴认知障碍组(PDD),20例年龄、性别匹配的健康体检者作为对照组(control).3组均进行脑葡萄糖代谢显像(18F-FDG-PET)并应用统计参数图(SPM)进行数据分析,比较各组间脑内葡萄糖代谢变化的差异和特点.结果 (1)1与对照组比较,PD-NC组出现枕叶(-24,-92,10)、顶叶(52,8,-32)、颞叶(-48,12,-16)代谢减低.(2)与对照组比较,PDD组出现广泛皮质(额、顶、颞、枕、边缘叶)代谢减低.(3)PDD组与PD-NC组相比,顶叶(-42,-48,40)、枕叶(-22,-96,-6)、颞叶(-42,-58,16)出现代谢减低加重.结论 PD-NC组已经出现大脑皮质代谢减低,随着PD认知功能障碍的进展,PD患者出现葡萄糖代谢减低的范围逐渐扩大,代谢减低的程度逐渐增加.这些特征有助于帕金森病伴认知功能障碍的诊断和鉴别诊断.
목적 탐토반인지공능장애파금삼병(Parkinson's discase,PD)적뇌포도당대사특정화변화과정,심구PD인지상관적신형생물학표지물.방법 장림상진단위원발성파금삼병환자50례진행MMSE평분,분위25례인지공능정상조(PD-NC)、25례반인지장애조(PDD),20례년령、성별필배적건강체검자작위대조조(control).3조균진행뇌포도당대사현상(18F-FDG-PET)병응용통계삼수도(SPM)진행수거분석,비교각조간뇌내포도당대사변화적차이화특점.결과 (1)1여대조조비교,PD-NC조출현침협(-24,-92,10)、정협(52,8,-32)、섭협(-48,12,-16)대사감저.(2)여대조조비교,PDD조출현엄범피질(액、정、섭、침、변연협)대사감저.(3)PDD조여PD-NC조상비,정협(-42,-48,40)、침협(-22,-96,-6)、섭협(-42,-58,16)출현대사감저가중.결론 PD-NC조이경출현대뇌피질대사감저,수착PD인지공능장애적진전,PD환자출현포도당대사감저적범위축점확대,대사감저적정도축점증가.저사특정유조우파금삼병반인지공능장애적진단화감별진단.
Objective To investigate the change of the cerebral glucose metabolism in Parkinson's disease(PD) with cognitive impairment.Methods Fifty patients with PD and twenty normal controls were enrolled in this study.Based on MMSE score,the PD patients were divided into PD-NC(n=25) and the PDD(n=25) group.Twenty age-and sex-matched physical health examinationer were colleted as control group.Using the SPM to analyze the characteristics of the metabolism in different cognitive level io PD patients.Results (1) Compared with control group,P D-NC group showed significant hypermetabolism in occipital (-24,-92,10),parietal (-48,12,-16) and temporal lobe(52,8,-32).(2)Compared with control group,the glucose metabolism of PDD group decreased in most cerebral cortex and subcortex.(3)Compared with PD-NC group,the metabolism of parietal lobe (-42,-48,40),occipital lobe (-22,-96,-6) and tetnporal lobe (-42,-58,16) reduced in PDD group.Conclusion Cortical brain metabolism decreases in PD-NC group.The degree and scope of glucose metabolism of PDD group will increase with the progress of cognitive dysfunction.These features could help with the diagnosis and differential diagnosis of cognitive dysfunction in Parkinson's disease.