CAJ | 학술논문

噬菌体展示技术是将外源性基因通过基因工程手段与噬菌体基因融合，使外源基因编码的多肽呈现在噬菌体表面，并保持外源性多肽相对独立的空间结构和生物活性。近期研究表明，利用噬菌体展示技术可进行肿瘤靶向肽的筛选、抗癌物质的靶向输送、肿瘤疫苗的研制、肿瘤抗体的制备、肿瘤诊断试剂的研发、肿瘤血管的光学成像等，进而为攻克肿瘤这一医学难题提供帮助。
서균체전시기술시장외원성기인통과기인공정수단여서균체기인융합，사외원기인편마적다태정현재서균체표면，병보지외원성다태상대독립적공간결구화생물활성。근기연구표명，이용서균체전시기술가진행종류파향태적사선、항암물질적파향수송、종류역묘적연제、종류항체적제비、종류진단시제적연발、종류혈관적광학성상등，진이위공극종류저일의학난제제공방조。
Phage display technology describes a genetic engineering technique in which a library of peptide or protein variants is expressed on the outside of a phage virion,while the genetic material encodes each variant resides on the inside and maintains the relatively independent spatial structure and biological activity. Studies have shown that the phage display technology can be used to screen tumor homing peptides,target trans-porting anti-substances,develop vaccines,research diagnostic regents and image in blood vessels.Thus phage display technology is a powerful method to overcome the challenge of tumor disease.