中国综合临床
中國綜閤臨床
중국종합림상
Clinical Medicine of China
2015年
9期
820-822
,共3页
失眠症%川芎清脑颗粒%艾司唑仑%匹兹堡睡眠质量指数
失眠癥%川芎清腦顆粒%艾司唑崙%匹玆堡睡眠質量指數
실면증%천궁청뇌과립%애사서륜%필자보수면질량지수
Insomnia%Chuanxiongqingnaokeli%Estazolam%Pittsburgh sleep quality index
目的 观察川芎清脑颗粒治疗失眠症的临床效果.方法 选择2012年1月至2013年7月我院诊治的失眠症患者82例,将患者随机分为治疗组42例和对照组40例.治疗组采用川芎清脑颗粒联合艾司唑仑片治疗,对照组单独服用艾司唑仑片治疗.观察治疗前、后两组患者的入睡时间、易醒次数、睡眠维持时间、匹兹堡睡眠质量指数评分的变化,以及次日宿醉情况.结果 治疗后两组患者匹兹堡睡眠质量指数评分均较治疗前明显降低[治疗组治疗前、后分别为(14.92±2.89)、(3.35±1.72)分,t=2.421,P＜0.05;对照组分别为(15.20±3.02)、(5.81±2.31)分,t=2.537,P＜0.05)],且治疗组降低效果优于对照组,差异有统计学意义(t=4.478,P＜0.05).治疗组易醒次数(1.49±1.42)次、睡眠维持时间(5.78±1.23)h、次日宿醉现象(0)均明显优于对照组[(2.54±1.56)次、(4.09±1.52)h、37.5％],差异均有统计学意义(P均＜0.05).治疗组总有效率90.5％(38/42)高于对照组的72.5％(29/40),差异有统计学意义(x2=61.42,P＜0.05).结论 川芎清脑颗粒治疗失眠症有显著的临床疗效,尤其可改善易醒次数及睡眠维持时间,同时还可缓解因服用镇静催眠药所致的次日宿醉现象等不良反应.
目的 觀察川芎清腦顆粒治療失眠癥的臨床效果.方法 選擇2012年1月至2013年7月我院診治的失眠癥患者82例,將患者隨機分為治療組42例和對照組40例.治療組採用川芎清腦顆粒聯閤艾司唑崙片治療,對照組單獨服用艾司唑崙片治療.觀察治療前、後兩組患者的入睡時間、易醒次數、睡眠維持時間、匹玆堡睡眠質量指數評分的變化,以及次日宿醉情況.結果 治療後兩組患者匹玆堡睡眠質量指數評分均較治療前明顯降低[治療組治療前、後分彆為(14.92±2.89)、(3.35±1.72)分,t=2.421,P＜0.05;對照組分彆為(15.20±3.02)、(5.81±2.31)分,t=2.537,P＜0.05)],且治療組降低效果優于對照組,差異有統計學意義(t=4.478,P＜0.05).治療組易醒次數(1.49±1.42)次、睡眠維持時間(5.78±1.23)h、次日宿醉現象(0)均明顯優于對照組[(2.54±1.56)次、(4.09±1.52)h、37.5％],差異均有統計學意義(P均＜0.05).治療組總有效率90.5％(38/42)高于對照組的72.5％(29/40),差異有統計學意義(x2=61.42,P＜0.05).結論 川芎清腦顆粒治療失眠癥有顯著的臨床療效,尤其可改善易醒次數及睡眠維持時間,同時還可緩解因服用鎮靜催眠藥所緻的次日宿醉現象等不良反應.
목적 관찰천궁청뇌과립치료실면증적림상효과.방법 선택2012년1월지2013년7월아원진치적실면증환자82례,장환자수궤분위치료조42례화대조조40례.치료조채용천궁청뇌과립연합애사서륜편치료,대조조단독복용애사서륜편치료.관찰치료전、후량조환자적입수시간、역성차수、수면유지시간、필자보수면질량지수평분적변화,이급차일숙취정황.결과 치료후량조환자필자보수면질량지수평분균교치료전명현강저[치료조치료전、후분별위(14.92±2.89)、(3.35±1.72)분,t=2.421,P＜0.05;대조조분별위(15.20±3.02)、(5.81±2.31)분,t=2.537,P＜0.05)],차치료조강저효과우우대조조,차이유통계학의의(t=4.478,P＜0.05).치료조역성차수(1.49±1.42)차、수면유지시간(5.78±1.23)h、차일숙취현상(0)균명현우우대조조[(2.54±1.56)차、(4.09±1.52)h、37.5％],차이균유통계학의의(P균＜0.05).치료조총유효솔90.5％(38/42)고우대조조적72.5％(29/40),차이유통계학의의(x2=61.42,P＜0.05).결론 천궁청뇌과립치료실면증유현저적림상료효,우기가개선역성차수급수면유지시간,동시환가완해인복용진정최면약소치적차일숙취현상등불량반응.
Objective To observe the clinical effects of Chuanxiongqingnaokeli for treatment of insomnia.Methods Eighty-two cases of insomnia patients were randomly divided into treatment group (n =42)and control group (n=40) who were treated in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2012 to July 2013.The treatment group was administrated Chuanxiongqingnaokeli combined with estazolam tablets while control group was administrated estazolam tablets alone.The indicators including sleep time,easy to waking,sleep time,Pittsburgh sleep quality index and hangover on next day were observed before and after treatment.Results The Pittsburgh sleep quality index of both groups were significantly lower after treatment (treatment group:14.92± 2.89 vs.3.35 ± 1.72,t =2.421,P＜0.05;control group:15.20±3.02 vs.5.81±2.31 score,t=2.537,P＜0.05).And the treatment effect of treatment group was better than control group(t =4.478,P＜0.05).Easy to waking time of the treatment group was (1.49± 1.42) times,sleeping time was (5.78± 1.23) h,hangover on next day was 0,all these data were better than that of control group(2.54±1.56) times,(4.09±1.52) h,37.5％;P＜0.05).The total effective rate of treatment group was 90.5％ (38/42),significantly higher than that of control group (72.5％ (29/40);x2 =61.42,P ＜0.05).Conclusion The chuanxiongqingnaokeli has the significant effects for patients with insomnia.It has more improved in easy to waking and maintaining sleep time significantly which accompanied with advantage of relieving hangover on next day induced by sedative hypnotics at the same time.
