中国综合临床
中國綜閤臨床
중국종합림상
Clinical Medicine of China
2015年
9期
817-819
,共3页
急性脑梗死%尿酸%C反应蛋白%纤维蛋白原%危险因素
急性腦梗死%尿痠%C反應蛋白%纖維蛋白原%危險因素
급성뇌경사%뇨산%C반응단백%섬유단백원%위험인소
Acute cerebral infarction%Uric acid%C-reactive protein%Fibrinogen%Risk factors
目的 探讨急性脑梗死患者血清尿酸(UA)、C反应蛋白(CRP)和纤维蛋白原(Fg)水平变化及其临床意义.方法 选择急性脑梗死96例患者为研究对象(急性脑梗死组),同期选取90名健康查体者作为对照组.并将急性脑梗死96例患者按照病情轻重分为轻型组(52例)、中型组(32例)和重型组(12例).比较急性脑梗死组患者与对照组血清UA、CRP和Fg水平差异,并进一步比较急性脑梗死患者不同亚组间的差异;分析急性脑梗死患者血清UA、Fg与CRP的相关性.结果 急性脑梗死组相关指标水平均明显高于对照组[血清UA:(423.6±46.5)μmol/L与(302.4±28.7)μmol/L,t=4.758,P＜0.05;CRP:(15.6±2.3)mg/L与(1.9±0.8) mg/L,t=14.547,P＜0.05;Fg:(4.6± 1.4) g/L与(3.1±0.9)g/L,t=3.936,P＜0.05],差异均有统计学意义.急性脑梗死患者轻、中、重型组血清UA[(366.2±23.5)、(398.4± 32.7)、(457.4± 56.2)μmol/L,F=7.646,P＜0.05]、CRP[(7.4±1.6)、(14.6±1.9)、(22.8±4.6)mg/L,F=9.837,P＜0.05]、Fg[(3.3±1.4)、(3.9±1.5)、(5.2±2.1)g/L,F=5.757,P＜0.05]随着病情的加重呈逐渐上升趋势,差异有统计学意义.相关性分析显示,急性脑梗死患者血清UA与CRP呈正相关(r=0.683,P＜0.05);Fg水平与CRP呈正相关(r=0.564,P＜0.05).结论 急性脑梗死患者血清UA、CRP和Fg水平明显升高,可作为预测急性脑梗死发生的危险因素.
目的 探討急性腦梗死患者血清尿痠(UA)、C反應蛋白(CRP)和纖維蛋白原(Fg)水平變化及其臨床意義.方法 選擇急性腦梗死96例患者為研究對象(急性腦梗死組),同期選取90名健康查體者作為對照組.併將急性腦梗死96例患者按照病情輕重分為輕型組(52例)、中型組(32例)和重型組(12例).比較急性腦梗死組患者與對照組血清UA、CRP和Fg水平差異,併進一步比較急性腦梗死患者不同亞組間的差異;分析急性腦梗死患者血清UA、Fg與CRP的相關性.結果 急性腦梗死組相關指標水平均明顯高于對照組[血清UA:(423.6±46.5)μmol/L與(302.4±28.7)μmol/L,t=4.758,P＜0.05;CRP:(15.6±2.3)mg/L與(1.9±0.8) mg/L,t=14.547,P＜0.05;Fg:(4.6± 1.4) g/L與(3.1±0.9)g/L,t=3.936,P＜0.05],差異均有統計學意義.急性腦梗死患者輕、中、重型組血清UA[(366.2±23.5)、(398.4± 32.7)、(457.4± 56.2)μmol/L,F=7.646,P＜0.05]、CRP[(7.4±1.6)、(14.6±1.9)、(22.8±4.6)mg/L,F=9.837,P＜0.05]、Fg[(3.3±1.4)、(3.9±1.5)、(5.2±2.1)g/L,F=5.757,P＜0.05]隨著病情的加重呈逐漸上升趨勢,差異有統計學意義.相關性分析顯示,急性腦梗死患者血清UA與CRP呈正相關(r=0.683,P＜0.05);Fg水平與CRP呈正相關(r=0.564,P＜0.05).結論 急性腦梗死患者血清UA、CRP和Fg水平明顯升高,可作為預測急性腦梗死髮生的危險因素.
목적 탐토급성뇌경사환자혈청뇨산(UA)、C반응단백(CRP)화섬유단백원(Fg)수평변화급기림상의의.방법 선택급성뇌경사96례환자위연구대상(급성뇌경사조),동기선취90명건강사체자작위대조조.병장급성뇌경사96례환자안조병정경중분위경형조(52례)、중형조(32례)화중형조(12례).비교급성뇌경사조환자여대조조혈청UA、CRP화Fg수평차이,병진일보비교급성뇌경사환자불동아조간적차이;분석급성뇌경사환자혈청UA、Fg여CRP적상관성.결과 급성뇌경사조상관지표수평균명현고우대조조[혈청UA:(423.6±46.5)μmol/L여(302.4±28.7)μmol/L,t=4.758,P＜0.05;CRP:(15.6±2.3)mg/L여(1.9±0.8) mg/L,t=14.547,P＜0.05;Fg:(4.6± 1.4) g/L여(3.1±0.9)g/L,t=3.936,P＜0.05],차이균유통계학의의.급성뇌경사환자경、중、중형조혈청UA[(366.2±23.5)、(398.4± 32.7)、(457.4± 56.2)μmol/L,F=7.646,P＜0.05]、CRP[(7.4±1.6)、(14.6±1.9)、(22.8±4.6)mg/L,F=9.837,P＜0.05]、Fg[(3.3±1.4)、(3.9±1.5)、(5.2±2.1)g/L,F=5.757,P＜0.05]수착병정적가중정축점상승추세,차이유통계학의의.상관성분석현시,급성뇌경사환자혈청UA여CRP정정상관(r=0.683,P＜0.05);Fg수평여CRP정정상관(r=0.564,P＜0.05).결론 급성뇌경사환자혈청UA、CRP화Fg수평명현승고,가작위예측급성뇌경사발생적위험인소.
Objective To discuss the clinical significance of change of serum uric acid (UA),C-reactive protein(CRP) and fibrinogen(Fg) levels in patients with acute cerebral infarction.Methods Ninetysix patients with acute cerebral infarction were divided into the mild group (n =52),middle group(n =32) and heavy group(n =12) according to illness degree,and 90 healthy person were selected as the control group.The serum UA,CRP and Fg of all groups were compared.Correlation analysis of serum UA,Fg and CRP in patients with acute cerebral infarction was carried.Results The level of serum UA((423.6±46.5) μmol/L vs.(302.4±28.7) μmol/L,t=4.758,P＜0.05),CRP((15.6±2.3) mg/L vs.(1.9±0.8) mg/L,t =14.547,P＜0.05) and Fg((4.6± 1.4) g/L vs.(3.1 ±0.9) g/L,t =3.936,P＜ 0.05) of acute cerebral infarction group were all obviously higher than that of control group,the differences were statistically significant(P＜0.05).The levels of serum UA((366.2±23.5) μmol/L,(398.4± 32.7) μmol/L and (457.4± 56.2) μmol/L,F =7.646),CRP ((7.4±1.6) mg/L,(14.6±1.9) mg/L and (22.8±4.6) mg/L,F=9.837) and Fg((3.3±1.4) g/L,(3.9 ± 1.5) g/L and (5.2 ± 2.1) g/L,F =5.757) of mild,middle and heavy groups rise with illness degree,differences were all statistically significance(P＜0.05).Correlation analysis showed that serum UA,CRP levels and Fg,CRP were positively correlated (r =0.683,0.564),the differences were statistically significant (P ＜0.05).Conclusion Serum UA,CRP and Fg levels in patients with acute cerebral infarction obviously increase and they can be regarded as to predict risk factors of cerebral infarction.
