中国综合临床
中國綜閤臨床
중국종합림상
Clinical Medicine of China
2015年
9期
812-816
,共5页
朱峰%王来明%季春鹏%刘志亮%杨春香%王志美%吴寿岭
硃峰%王來明%季春鵬%劉誌亮%楊春香%王誌美%吳壽嶺
주봉%왕래명%계춘붕%류지량%양춘향%왕지미%오수령
C反应蛋白%非酒精性脂肪性肝病%多因素Logistic回归模型
C反應蛋白%非酒精性脂肪性肝病%多因素Logistic迴歸模型
C반응단백%비주정성지방성간병%다인소Logistic회귀모형
C-reactive protein%Nonalcoholic fatty liver disease%Multiple logistic regression
目的 探讨C反应蛋白(CRP)与非酒精性脂肪性肝病(NAFLD)的关系.方法 选择2012年7月至2013年10月健康体检的开滦集团公司职工为研究对象,排除饮酒者、既往心肌梗死、脑卒中、恶性肿瘤以及资料不全者,最终63 486例纳入本研究,将研究对象按血清CRP浓度分为3组,即CRP＜1 mg/L组、CRP 1～3 mg/L组和CRP＞3 mg/L组,比较各组NAFLD患者的检出率并采用多因素Logistic回归模型分析CRP与NAFLD的关系.结果 CRP＜1 mg/L组、CRP 1～3 mg/L组和CRP＞3 mg/L组NAFLD检出率分别为26.9％、42.1％和49.3％,3组比较差异有统计学意义(x2=2 192.31,P＜0.01).校正年龄、性别、腰围等混杂因素后,CRP仍与NAFLD有关联,且随着CRP浓度的增加,OR(95％ CI)值逐渐增高,分别为1.00、1.49(1.42～1.56)和1.54(1.45～1.64).结论 CRP与NAFLD发生有关联.
目的 探討C反應蛋白(CRP)與非酒精性脂肪性肝病(NAFLD)的關繫.方法 選擇2012年7月至2013年10月健康體檢的開灤集糰公司職工為研究對象,排除飲酒者、既往心肌梗死、腦卒中、噁性腫瘤以及資料不全者,最終63 486例納入本研究,將研究對象按血清CRP濃度分為3組,即CRP＜1 mg/L組、CRP 1～3 mg/L組和CRP＞3 mg/L組,比較各組NAFLD患者的檢齣率併採用多因素Logistic迴歸模型分析CRP與NAFLD的關繫.結果 CRP＜1 mg/L組、CRP 1～3 mg/L組和CRP＞3 mg/L組NAFLD檢齣率分彆為26.9％、42.1％和49.3％,3組比較差異有統計學意義(x2=2 192.31,P＜0.01).校正年齡、性彆、腰圍等混雜因素後,CRP仍與NAFLD有關聯,且隨著CRP濃度的增加,OR(95％ CI)值逐漸增高,分彆為1.00、1.49(1.42～1.56)和1.54(1.45～1.64).結論 CRP與NAFLD髮生有關聯.
목적 탐토C반응단백(CRP)여비주정성지방성간병(NAFLD)적관계.방법 선택2012년7월지2013년10월건강체검적개란집단공사직공위연구대상,배제음주자、기왕심기경사、뇌졸중、악성종류이급자료불전자,최종63 486례납입본연구,장연구대상안혈청CRP농도분위3조,즉CRP＜1 mg/L조、CRP 1～3 mg/L조화CRP＞3 mg/L조,비교각조NAFLD환자적검출솔병채용다인소Logistic회귀모형분석CRP여NAFLD적관계.결과 CRP＜1 mg/L조、CRP 1～3 mg/L조화CRP＞3 mg/L조NAFLD검출솔분별위26.9％、42.1％화49.3％,3조비교차이유통계학의의(x2=2 192.31,P＜0.01).교정년령、성별、요위등혼잡인소후,CRP잉여NAFLD유관련,차수착CRP농도적증가,OR(95％ CI)치축점증고,분별위1.00、1.49(1.42～1.56)화1.54(1.45～1.64).결론 CRP여NAFLD발생유관련.
Objective To investigate the relationship between the C-reactive protein (CRP) and nonalcoholic fatty liver disease (NAFLD) prevalence.Methods In this study,63,486 workers who had participated in the Kailuan health examination from July 2012 to October 2013 and without history of drinking,myocardial infarction,stroke and cancer and without data incomplete were recruited.The observation population was divided into three groups according to the levels of CRP at baseline:group 1 (＜ 1 mg/L),group 2 (1-3 mg/ L) and group 3 (＞3 mg/L).The prevalence of NAFLD among three groups was observed.Multiple logistic regression was used to calculated relationship between the CRP and NAFLD prevalence.Results The prevalence of NAFLD in group 1,group 2 and group 3 were 26.9％,42.1％ and 49.3％,respectively,and the differences were significant (x2=2 192.31,P ＜ 0.01).Logistic model showed that after adjustment for age,gender,waist circumference and other confounders,the association between CRP and NAFLD was strong and the OR value (95％ CI) among the group 1,group 2 and group 3 were 1.00,1.49 (1.42-1.56),1.54 (1.45 -1.64),respectively.Conclusion CRP is independently associated with the nonalcoholic fatty liver disease.
