CAJ | 학술논문

DNA 甲基化与脑胶质瘤的发生发展关系密切。胶质瘤中的许多基因如 DNA 修复基因、细胞周期调控基因、细胞凋亡相关基因、肿瘤抑制基因、侵袭相关基因等的启动子区胞嘧啶-磷酸-鸟嘌呤位点富集区（CpG 岛）存在高甲基化。胶质瘤多个基因的甲基化谱和特异分子标志物的发现有助于胶质瘤的病理分级、早期诊断、判断预后。同时，DNA 甲基化具有可逆转的特性，这可能为胶质瘤的治疗提供新的途径。
DNA 갑기화여뇌효질류적발생발전관계밀절。효질류중적허다기인여 DNA 수복기인、세포주기조공기인、세포조망상관기인、종류억제기인、침습상관기인등적계동자구포밀정-린산-조표령위점부집구（CpG 도）존재고갑기화。효질류다개기인적갑기화보화특이분자표지물적발현유조우효질류적병리분급、조기진단、판단예후。동시，DNA 갑기화구유가역전적특성，저가능위효질류적치료제공신적도경。
DNA methylation is closely related to the genesis and development of glioma.The CpG islands hypermethylation in promoter region of DNA repair genes,cell cycle controlling genes,apoptosis related genes,tumor suppressor genes and invasion related genes are found in glioma.Finding the specific methylation profile and molecular marker of glioma is helpful for the pathology class,early diagnosis and prognostic evalua-tion.Meanwhile,DNA methylation has the characteristic of reversibility,which may provide new ways for the treatment of glioma.