CAJ | 학술논문

目的：探讨 G4射波刀治疗大肝癌后肝功能情况，评估其治疗安全性。方法回顾性分析63例行 G4射波刀治疗大肝癌患者，比较放疗前与放疗后肝功能情况，并行统计学分析。结果G4射波刀治疗后12个月谷丙转氨酶（ALT）、碱性磷酸酶（ALP）、总胆红素（TBIL）、活动度（PA）分别为23．00 U ／L、111．00 U ／L、13．70μmol／L、（81．87±13．94）％，与治疗前[28．00 U ／L、32．00 U ／L、11．30μmol／L、（86．07±14．07）％]相比差异均无统计学意义（Z ＝－1．677，P ＝0．094；Z ＝－0．504，P ＝0．614；Z ＝－1．945，P ＝0．053；t ＝1．271，P ＝0．213）。G4射波刀治疗后12个月白蛋白（ALB）为（34．84±4．75）g／L，较治疗前[（37．45±4．14）g／L]下降，差异有统计学意义（t ＝3．357，P ＝0．002）。G4射波刀治疗后12个月肝功能 Child-Pugh 分级为5．80±1．17，与治疗前（5．48±0．81）相比差异无统计学意义（t ＝－1．668，P ＝0．106）。结论G4射波刀治疗大肝癌未引起肝功能损伤，安全、可靠，值得临床广泛推广。
목적：탐토 G4사파도치료대간암후간공능정황，평고기치료안전성。방법회고성분석63례행 G4사파도치료대간암환자，비교방료전여방료후간공능정황，병행통계학분석。결과G4사파도치료후12개월곡병전안매（ALT）、감성린산매（ALP）、총담홍소（TBIL）、활동도（PA）분별위23．00 U ／L、111．00 U ／L、13．70μmol／L、（81．87±13．94）％，여치료전[28．00 U ／L、32．00 U ／L、11．30μmol／L、（86．07±14．07）％]상비차이균무통계학의의（Z ＝－1．677，P ＝0．094；Z ＝－0．504，P ＝0．614；Z ＝－1．945，P ＝0．053；t ＝1．271，P ＝0．213）。G4사파도치료후12개월백단백（ALB）위（34．84±4．75）g／L，교치료전[（37．45±4．14）g／L]하강，차이유통계학의의（t ＝3．357，P ＝0．002）。G4사파도치료후12개월간공능 Child-Pugh 분급위5．80±1．17，여치료전（5．48±0．81）상비차이무통계학의의（t ＝－1．668，P ＝0．106）。결론G4사파도치료대간암미인기간공능손상，안전、가고，치득림상엄범추엄。
Objective To explore the influence of G4 cyberknife treatment of large hepatocellular car-cinoma on liver function,and to evaluate its treatment safety.Methods Sixty-three large liver cancer patients treated with routine G4 cyberknife treatment were retrospectively analyzed,and then statistical analysis of the difference in liver function before and after treatment was conducted.Results After G4 cyberknife treatment of 1 2 months,the levels of ALT,ALP,TBIL,PA were respectively 23.00 U /L,1 1 1 .00 U /L,1 3.70 μmol/L, (81 .87 ±1 3.94)%.Compared with the levels before treatment [28.00 U /L,32.00 U /L,1 1 .30 μmol/L, (86.07 ±1 4.07)%],there were no signi-ficant differences found (Z =-1 .677,P =0.094;Z =-0.504, P =0.61 4;Z =-1 .945,P =0.053;t =1 .271 ,P =0.21 3).The level of ambumin was (34.84 ±4.75)g/L at 1 2 months after treatment,which decreased and the difference compared with the level before treatment [(37.45 ±4.1 4)g/L]was significant (t =3.357,P =0.002).The Child-Pugh grade was 5.80 ±1 .1 7 respectively at the time points of 1 2 months after treatment,and no significant difference was found compared with the Child-Pugh grade before treatment (5.48 ±0.81 ,t =-1 .668,P =0.1 06).Conclusion G4 cyberknife treatment does not cause liver injury.It is safe and reliable in large liver cancer treatment.So,it is worth widely clinical popularizing.