CAJ | 학술논문

目的：调查南宁市妇女高危型人乳头状病毒(HPV)感染状态及危险因素。方法2014年1~6月，在该院妇科门诊就诊自愿参加进行宫颈癌机会性筛查及问卷调查的妇女431名为研究对象，收集她们的人口学信息和相关危险因素信息，并行常规妇科检查、生殖道微生物检测、宫颈细胞第2代杂交捕获技术(HC2)检测、细胞学检查。对可疑宫颈上皮内瘤变或宫颈癌患者行阴道镜检查活检，并进行组织病理学诊断。结果431名调查对象中，高危型 HPV 感染54例，感染率12.53%。在宫颈病变组与宫颈正常组中，高危型 HPV 阳性率分别为87.50%和9.64%，两者比较差异有统计学意义(P >0.05)。单因素及多因素研究分析，多个性伴侣(≥2个)和病原菌感染(尤其是细菌性阴道炎)是高危型 HPV 感染的高危因素。对阴道微生态环境的多因素分析显示，病原菌感染和细菌性阴道病是 HPV 病毒感染的高危因素。结论宫颈病变组中 HPV 感染率高于宫颈正常组，而初次性生活年龄早、多个性伴侣、病原菌感染、细菌性阴道病是 HPV 感染的危险因素。
목적：조사남저시부녀고위형인유두상병독(HPV)감염상태급위험인소。방법2014년1~6월，재해원부과문진취진자원삼가진행궁경암궤회성사사급문권조사적부녀431명위연구대상，수집저문적인구학신식화상관위험인소신식，병행상규부과검사、생식도미생물검측、궁경세포제2대잡교포획기술(HC2)검측、세포학검사。대가의궁경상피내류변혹궁경암환자행음도경검사활검，병진행조직병이학진단。결과431명조사대상중，고위형 HPV 감염54례，감염솔12.53%。재궁경병변조여궁경정상조중，고위형 HPV 양성솔분별위87.50%화9.64%，량자비교차이유통계학의의(P >0.05)。단인소급다인소연구분석，다개성반려(≥2개)화병원균감염(우기시세균성음도염)시고위형 HPV 감염적고위인소。대음도미생태배경적다인소분석현시，병원균감염화세균성음도병시 HPV 병독감염적고위인소。결론궁경병변조중 HPV 감염솔고우궁경정상조，이초차성생활년령조、다개성반려、병원균감염、세균성음도병시 HPV 감염적위험인소。
Objective This study evaluates the prevalence and factors related to high-risk human papilloma virus (HR-HPV) infection in Nanning adult women.Methods A total of 431 women who presented cervical cancer screening in (gynecological clinic, maternal and child health hospital of the Guangxi Zhuang Autonomous)were selected as subjects,from January to June,2014.A standardize questionnaire regarding demographic characteristics and possible risk factors of cervical cancer was filled by each partici-pant.Routine gynecological examination,microbial detection of reproductive tract,cervical cell HC2 test,cervical cytological and HPV DNA testing were applied to all participantes.Individuals who were suspicious for cervical intraepithelial neoplasia or cervical cancer received colposcopy biopsy and histopathological diagnosis.The date were analyzed in SPSS 1 9.0.Results Out of the total number of 431 samples.54 (12.53%)subjects were positive for HR-HPV.Among women with cervical abnormalities,82.50%had HR-HPV infection compared to 9.64% of those women with healthy cervix (P <0.01.Analysis for risk factors of HPV infec-tion showed that extramarital sexnal behaviors and maltiple sexual partners would increase the risk of HPV positivity.For vaginal micro ecological environment of multi-factor analysis showed that pathogen infection and bacterial vaginal disease are risk factors of HPV infection.Conclusion Among women with cervical abnormalities,HR-HPV positivity was significantly higher than that a-mong women with normal cervix.extramarital sexnal behaviors,multiple parity,pathogen infection and bacterial vaginal disease in-crease the risk of HPV infection.