CAJ | 학술논문

骨关节炎(OA)的影像学诊断方法主要包括X线片、CT、MRI、B超检查等,在特异性、敏感性和运用等方面各有侧重.与上述传统影像学检查手段相比较,近年来发展起来的Micro-CT、小动物核磁影像等高分辨率小动物影像学技术,不论在图像清晰度、细微结构显示方面,还是在定量分析方面都具有明显优势,在OA动物模型研究中发挥着重要作用.该文简述OA动物模型的建立,介绍各影像学技术的特点,综述Micro-CT在OA动物模型骨性结构成像和软骨成像中的作用,并从关节软骨成像序列选择、软骨厚度测量、软骨成分分析、其他组织病变分析等方面探讨小动物核磁影像技术在OA动物模型中的应用价值,同时对小动物影像学技术在OA动物模型应用的未来前景进行展望.
골관절염(OA)적영상학진단방법주요포괄X선편、CT、MRI、B초검사등,재특이성、민감성화운용등방면각유측중.여상술전통영상학검사수단상비교,근년래발전기래적Micro-CT、소동물핵자영상등고분변솔소동물영상학기술,불론재도상청석도、세미결구현시방면,환시재정량분석방면도구유명현우세,재OA동물모형연구중발휘착중요작용.해문간술OA동물모형적건립,개소각영상학기술적특점,종술Micro-CT재OA동물모형골성결구성상화연골성상중적작용,병종관절연골성상서렬선택、연골후도측량、연골성분분석、기타조직병변분석등방면탐토소동물핵자영상기술재OA동물모형중적응용개치,동시대소동물영상학기술재OA동물모형응용적미래전경진행전망.
Imaging diagnostic methods of osteoarthritis (OA) mainly include X-ray films,CT,MRI and ultrasound,etc.,which have their own characteristics in terms of the specificity,sensitivity and the utilization.Compared with the above traditional imaging examination means,high-resolution small animal imaging technology such as Micro-CT and nuclear magnetic imaging developed in recent years is showing obvious advantages in image resolution,microscopic structure display,as well as quantitative analysis,and playing important role in the study of OA animal models.In this paper,the establishment of OA animal model and the characteristics of various imaging techniques were introduced,the roles of bony structure imaging and cartilage imaging of Micro-CT in OA animal model were reviewed,the application values of small animal nuclear magnetic imaging in OA animal model were discussed from aspects of cartilage imaging sequences selection,cartilage thickness measurement,cartilage composition analysis and other tissue lesions analysis.At the same time,future prospects of small animal imaging technology in OA animal model were expected.