CAJ | 학술논문

Raf 激酶抑制蛋白（RKIP）已被证实在多条蛋白激酶信号通路的调节中发挥重要作用，与肿瘤关系密切。研究表明其在肿瘤中表达下调，机制涉及多方面，包括遗传调控和甲基化、乙酰化、组蛋白修饰、微小 RNA 调节等表观遗传学调控，并与 Snail、NF-κB 等蛋白形成环路调节。
Raf 격매억제단백（RKIP）이피증실재다조단백격매신호통로적조절중발휘중요작용，여종류관계밀절。연구표명기재종류중표체하조，궤제섭급다방면，포괄유전조공화갑기화、을선화、조단백수식、미소 RNA 조절등표관유전학조공，병여 Snail、NF-κB 등단백형성배로조절。
Raf kinase inhibiting protein (RKIP)plays a vital role in various physiological processes and participates in multiple signaling pathways,with a close releationgship with tumor.The mechanism of RKIP down-regulation in neoplasms includes transcriptional regulation,methylation,acetylation,histone modifica-tion,microRNA regulation and NF-κB/Snail/RKIP loop regulation.