CAJ | 학술논문

目的：探讨 GSTT1基因与中国人群结直肠癌易感性的关系。方法计算机检索PubMed、EMBase、Cochrane Library、中国生物医学文献数据库、维普中文科技期刊全文数据库、中国期刊全文数据库和万方医药期刊全文数据库，全面检索 GSTT1基因与中国人群结直肠癌易感性的临床对照研究。按纳入与排除标准筛选文献，对符合条件的研究由两位研究者独立进行资料提取和质量评价，采用 RevMan 5．1软件进行 Meta 分析。结果共检索出326篇文献，最终纳入10篇病例对照研究，其中结直肠癌患者2983例，对照组共纳入健康人4386例。Meta 分析结果显示 GSTT1基因是否缺失与结直肠癌易感性相关（RR ＝1．11，95％CI 为1．06～1．17，Z ＝4．26，P ＜0．0001）。结论在中国人群中 GSTT1基因缺失增加了结直肠癌的患病风险。
목적：탐토 GSTT1기인여중국인군결직장암역감성적관계。방법계산궤검색PubMed、EMBase、Cochrane Library、중국생물의학문헌수거고、유보중문과기기간전문수거고、중국기간전문수거고화만방의약기간전문수거고，전면검색 GSTT1기인여중국인군결직장암역감성적림상대조연구。안납입여배제표준사선문헌，대부합조건적연구유량위연구자독립진행자료제취화질량평개，채용 RevMan 5．1연건진행 Meta 분석。결과공검색출326편문헌，최종납입10편병례대조연구，기중결직장암환자2983례，대조조공납입건강인4386례。Meta 분석결과현시 GSTT1기인시부결실여결직장암역감성상관（RR ＝1．11，95％CI 위1．06～1．17，Z ＝4．26，P ＜0．0001）。결론재중국인군중 GSTT1기인결실증가료결직장암적환병풍험。
Objective To assess the association between glutathione S-transferase T1 (GSTT1 )gene and the susceptibility of colorectal cancer among Chinese population.Methods Clinical controlled trials of the association between GSTT1 and the susceptibility of colorectal cancer among Chinese population were searched in PubMed,EMBase,Cochrane Library,China Biology Medicine disc,VIP database,China National Knowledge Infrastructure and Wanfang database.According to the inclusion and exclusion criteria,data extraction and quali-ty assessment were done by two researchers independently.Outcomes were pooled with RevMan 5.1 .Results 326 studies were found and 10 clinical controlled trails including 2 983 cases of colorectal cancer and 4 386 cases of healthy objects were included in this analysis.The results of Meta-analysis showed that the lack of GSTT1 gene is associated with colorectal cancer susceptibility (RR =1 .11 ,95%CI:1 .06-1 .17,Z =4.26,P <0.000 1 ). Conclusion The loss of GSTT1 increase the risk of colorectal cancer among Chinese population.