CAJ | 학술논문

目的：探讨 MBD4蛋白在子宫内膜腺癌中的表达及临床意义。方法采用免疫组织化学 SP 法检测45例正常子宫内膜和60例子宫内膜腺癌中 MBD4蛋白的表达，并分析其与临床分期和病理分级的关系。结果MBD4蛋白在正常子宫内膜和子宫内膜腺癌中的阳性表达率分别为60%及25%，呈降低趋势，差异具有统计学意义(P <0.05)。MBD4蛋白的表达与子宫内膜腺癌的临床分期、病理分级、子宫肌层浸润深度、淋巴转移无相关性。结论MBD4蛋白的缺失在子宫内膜腺癌发病及治疗中有一定作用。
목적：탐토 MBD4단백재자궁내막선암중적표체급림상의의。방법채용면역조직화학 SP 법검측45례정상자궁내막화60례자궁내막선암중 MBD4단백적표체，병분석기여림상분기화병리분급적관계。결과MBD4단백재정상자궁내막화자궁내막선암중적양성표체솔분별위60%급25%，정강저추세，차이구유통계학의의(P <0.05)。MBD4단백적표체여자궁내막선암적림상분기、병리분급、자궁기층침윤심도、림파전이무상관성。결론MBD4단백적결실재자궁내막선암발병급치료중유일정작용。
Objective To study the expression and clinical significance of MBD4 protein in endometrial adenocarcinoma. Methods The MBD4 expression was examined by adopting the SP immunohistochemical method in 45 normal endometrial samples and 60 endometrial adenocarcinoma samples and to analyze its relationship with the clinical staging and pathologic grading.Results The positive expression rate of MBD4 protein in normal endometrium was 60%,which was significantly higher than 25% in endom-etrial adenocarcinoma,indicating the decreasing trend,the difference was statistically significant(P <0.05).The MBD4 protein ex-pression in endometrial adenocarcinoma had no obvious correlation with the clinical staging,pathologic stage,myometrium invasion depth and lymph node metastasis.Conclusion The lack of MBD4 protein in endometrial adenocarcinoma may play a role in the oc-currence and treatment of endometrial adenocarcinoma.