CAJ | 학술논문

目的了解九江市健康成年人群麻疹抗体水平，探讨成人麻疹疫苗免疫目标人群，为有效实施麻疹预防措施和控制策略提供依据。方法2013年对15岁以上健康人群共840名采用酶联免疫吸附试验(ELISA)法进行麻疹IgG抗体浓度检测。结果麻疹抗体阳性率85.71%，保护率50.12%，几何平均浓度(GMC)为1160.95IU/L。15-25岁、35-40岁年龄段人群的的麻疹IgG抗体水平、抗体阳性率和保护率均相对较低，未达到麻疹抗体保护水平；其中20-25岁年龄组抗体保护率水平仅为30.43%。男性与女性麻疹抗体阳性率和保护率之间无较大差异；但20-35岁女性麻疹抗体阳性率、保护率低于>35岁女性。城市居民麻疹抗体阳性率较农村居民低；常住人口麻疹抗体阳性率和保护率明显高于流动人口。结论在保证常规免疫覆盖率的基础上，可根据成人免疫状况适当调整麻疹免疫策略，开展成人麻疹疫苗免疫，重点针对15-40岁人群，其中以在校大中学生、育龄妇女、城市居民、流动居民和商业服务人群为主要接种对象。
목적료해구강시건강성년인군마진항체수평，탐토성인마진역묘면역목표인군，위유효실시마진예방조시화공제책략제공의거。방법2013년대15세이상건강인군공840명채용매련면역흡부시험(ELISA)법진행마진IgG항체농도검측。결과마진항체양성솔85.71%，보호솔50.12%，궤하평균농도(GMC)위1160.95IU/L。15-25세、35-40세년령단인군적적마진IgG항체수평、항체양성솔화보호솔균상대교저，미체도마진항체보호수평；기중20-25세년령조항체보호솔수평부위30.43%。남성여녀성마진항체양성솔화보호솔지간무교대차이；단20-35세녀성마진항체양성솔、보호솔저우>35세녀성。성시거민마진항체양성솔교농촌거민저；상주인구마진항체양성솔화보호솔명현고우류동인구。결론재보증상규면역복개솔적기출상，가근거성인면역상황괄당조정마진면역책략，개전성인마진역묘면역，중점침대15-40세인군，기중이재교대중학생、육령부녀、성시거민、류동거민화상업복무인군위주요접충대상。
Objective To investigate measles antibody levels among healthy adults in Jiujiang city,discuss measles vaccine target population,and provide effective prevention and control strategy of measles immunization. Methods Blood samples of 840 healthy adults over 15 years old were collected in 2013 and serum IgG antibody levels of measles were determined by ELISA. Results The measles antibody positive rate,the protective rate and the geometric mean concentration(GMC) were 85.71%,50.12%and 1160.95IU/L respectively. There were relatively lower measles antibody positive rate and the protection rates of measles anti-body among age groups of 15 to 25 and 35 to 40,which were not reach the protective level;The protection rates of measles anti-body among the group aged 20-25 were merely 30.43%. There were no significant difference of the measles antibody positive rate and the protection rates of measles antibody between male and female. But the measles antibody positive rate and the protection rates of measles antibody in the female aged 20 to 35 was lower than that of female over 35 years old. The urban resident measles antibody positive rate was lower than country residents;The measles antibody positive rate and the protection rates of measles anti-body in permanent residents was obviously higher than that in floating population. Conclusion In the guarantee on the basis of routine immunization coverage rate,adult vaccination can adjust measles immunization strategy according to the adult immune sta-tus. Adult vaccination should be focus on 15 to 40 years old,especially college students,women of reproductive age,permanent residents,floating population and commercial service people.