中国综合临床
中國綜閤臨床
중국종합림상
Clinical Medicine of China
2015年
9期
799-802
,共4页
于秀艳%柳治%张文艳%吴寿岭%董小波%惠颖%周瑞臣%高玉龙%张仲慧
于秀豔%柳治%張文豔%吳壽嶺%董小波%惠穎%週瑞臣%高玉龍%張仲慧
우수염%류치%장문염%오수령%동소파%혜영%주서신%고옥룡%장중혜
糖化血红蛋白%无症状性脑梗死%危险因素
糖化血紅蛋白%無癥狀性腦梗死%危險因素
당화혈홍단백%무증상성뇌경사%위험인소
HaemoglobinA1c%Silent cerebral infarct%Risk factors
目的 探讨糖化血红蛋白(HbA1c)对中青年男性无症状性脑梗死(SCI)的影响.方法 以2011年10-12月在开滦总医院健康查体的537名某单位在职高级管理人员作为研究对象,经头颅CT扫描检出SCI;采用多因素Logistic回归分析HbA1c水平对中青年男性SCI的影响.结果 (1)537例研究对象平均年龄为(48.68±5.74)岁.以HbA1c为6.0％为截点,将研究对象分为HbA1c正常组(HbA1c＜6.0％)和HbA1c增高组(HbA1c≥6.0％),其中HbA1c正常组468例,HbA1c增高组69例;(2)537例研究对象SCI的患病率为11.2％(60/537),HbA1c正常组及HbA1c增高组SCI的患病率分别为9.4％(44/468)及23.2％(16/69),组间比较差异有统计学意义(x2=11.516,P＜0.05);(3)影响SCI的Logistic回归分析显示在校正其他因素后HbA1c增高组发生SCI的风险是HbA1c正常组的2.242倍(95％CI:1.060～4.745,P=0.035).结论 HbA1c水平增高是中青年男性SCI的危险因素.
目的 探討糖化血紅蛋白(HbA1c)對中青年男性無癥狀性腦梗死(SCI)的影響.方法 以2011年10-12月在開灤總醫院健康查體的537名某單位在職高級管理人員作為研究對象,經頭顱CT掃描檢齣SCI;採用多因素Logistic迴歸分析HbA1c水平對中青年男性SCI的影響.結果 (1)537例研究對象平均年齡為(48.68±5.74)歲.以HbA1c為6.0％為截點,將研究對象分為HbA1c正常組(HbA1c＜6.0％)和HbA1c增高組(HbA1c≥6.0％),其中HbA1c正常組468例,HbA1c增高組69例;(2)537例研究對象SCI的患病率為11.2％(60/537),HbA1c正常組及HbA1c增高組SCI的患病率分彆為9.4％(44/468)及23.2％(16/69),組間比較差異有統計學意義(x2=11.516,P＜0.05);(3)影響SCI的Logistic迴歸分析顯示在校正其他因素後HbA1c增高組髮生SCI的風險是HbA1c正常組的2.242倍(95％CI:1.060～4.745,P=0.035).結論 HbA1c水平增高是中青年男性SCI的危險因素.
목적 탐토당화혈홍단백(HbA1c)대중청년남성무증상성뇌경사(SCI)적영향.방법 이2011년10-12월재개란총의원건강사체적537명모단위재직고급관리인원작위연구대상,경두로CT소묘검출SCI;채용다인소Logistic회귀분석HbA1c수평대중청년남성SCI적영향.결과 (1)537례연구대상평균년령위(48.68±5.74)세.이HbA1c위6.0％위절점,장연구대상분위HbA1c정상조(HbA1c＜6.0％)화HbA1c증고조(HbA1c≥6.0％),기중HbA1c정상조468례,HbA1c증고조69례;(2)537례연구대상SCI적환병솔위11.2％(60/537),HbA1c정상조급HbA1c증고조SCI적환병솔분별위9.4％(44/468)급23.2％(16/69),조간비교차이유통계학의의(x2=11.516,P＜0.05);(3)영향SCI적Logistic회귀분석현시재교정기타인소후HbA1c증고조발생SCI적풍험시HbA1c정상조적2.242배(95％CI:1.060～4.745,P=0.035).결론 HbA1c수평증고시중청년남성SCI적위험인소.
Objective To estimate the influence of haemoglobinAlc (HbA1c) for silent cerebral infarct (SCI) in young and mid-aged male individuals.Methods There were 537 cases of senior executives who came from the same unit and underwent the health examination which was proceed from October to December 2011 in Kailuan General Hospital.Detected by CT scan SCI.Multivariate logistic regression was used to analyze the influence of haemoglobinAc for silent cerebral infarct in young and mid-aged male individuals.Results (1) The baseline results showed that the average age of 537 subjects was 48.68±5.74 years old.All the subjects were divided into normal haemoglobinA1c group and high haemoglobinAlc group by HbA1c≥6.0％.There were 468 cases in normal haemoglobinA1c group and 69 cases in high haemoglobinA1c group.(2) The total prevalence of silent cerebral infarction in 537 individuals was 11.2％ (60/537) and the prevalence of silent cerebral infarct in normal haemoglobinA1c group and high haemoglobinA1c group were 9.4％ (44/468) and 23.2％ (16/69) respectively,and the difference between two groups was statistically significant (x2 =11.516,P ＜0.05).(3)Multiple logistic regression analysis showed that after adjusting for other risk factors,the high level of haemoglobinAlc was a risk factor for silent cerebral infarct,the OR value was 2.242(95％ CI:1.060-4.745,P=0.035).Conclusion High level of haemoglobinA1c was a risk factor for silent cerebral infarct in young and mid-aged male individuals.
